单剂量盐酸四环素与传统疗法治疗尿路感染的比较。
Comparison of single-dose tetracycline hydrochloride to conventional therapy of urinary tract infections.
作者信息
Rosenstock J, Smith L P, Gurney M, Lee K, Weinberg W G, Longfield J N, Tauber W B, Karney W W
出版信息
Antimicrob Agents Chemother. 1985 Apr;27(4):652-4. doi: 10.1128/AAC.27.4.652.
Abstract
Sixty-two women with signs and symptoms compatible with lower urinary tract infections were randomized to receive single-dose tetracycline (2 g), multi-dose tetracycline (500 mg four times per day for 10 days), or single-dose amoxicillin (3 g). Urine cultures were obtained upon entry into the study and on days 4, 14, and 28 after therapy. Single-dose tetracycline cured 12 of 16 (75%) of women with documented urinary tract infections, compared with 15 of 16 (94%) in the multi-dose tetracycline group and 7 of 13 (54%) receiving single-dose amoxicillin. Mild nausea in 3 of 20 patients (15%) was the only complication in the single-dose tetracycline group. Two grams of single-dose tetracycline is as effective as other reported regimens regardless of the susceptibility of the initial pathogen and has minimal toxicity.
摘要
62名有下尿路感染体征和症状的女性被随机分为三组，分别接受单剂量四环素（2克）、多剂量四环素（每日4次，每次500毫克，共10天）或单剂量阿莫西林（3克）治疗。在研究开始时以及治疗后的第4、14和28天采集尿培养样本。在有记录的尿路感染女性中，单剂量四环素组16人中有12人（75%）治愈，多剂量四环素组16人中有15人（94%）治愈，接受单剂量阿莫西林治疗的13人中有7人（54%）治愈。单剂量四环素组唯一的并发症是20名患者中有3人（15%）出现轻度恶心。无论初始病原体的敏感性如何，2克单剂量四环素与其他报道的治疗方案效果相同，且毒性极小。
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