睡前胰岛素注射：一种替代方案。
Bedtime insulin injections: an alternative regimen.
作者信息
Hinde F R, Johnston D I
出版信息
Arch Dis Child. 1985 Apr;60(4):311-5. doi: 10.1136/adc.60.4.311.
Abstract
Sixteen children (aged 3 to 12 years) participated in a 12 month crossover study comparing bedtime with teatime insulin injections in an endeavour to reduce morning hyperglycaemia. Blood glucose values were lower at lunch and at teatime on the later injection, but higher at bedtime and midnight. There was no overall change in glycosylated haemoglobin. Despite more frequent mild hypoglycaemic attacks, parents preferred the convenience of the later injection. Analysis of individual children's glycosylated haemoglobin values showed that those whose metabolic control improved on the later injection were younger and went to bed earlier, indicating that this regimen may have a place in the management of younger children with diabetes mellitus.
摘要
16名3至12岁的儿童参与了一项为期12个月的交叉研究，该研究比较了睡前注射胰岛素与下午茶时间注射胰岛素，以期降低早晨的高血糖水平。在较晚时间注射胰岛素时，午餐和下午茶时间的血糖值较低，但睡前和午夜时的血糖值较高。糖化血红蛋白水平没有总体变化。尽管轻度低血糖发作更为频繁，但家长们更喜欢较晚注射胰岛素带来的便利。对个别儿童糖化血红蛋白值的分析表明，那些在较晚时间注射胰岛素后代谢控制得到改善的儿童年龄较小且上床睡觉较早，这表明该方案在管理较年幼的糖尿病儿童方面可能有一席之地。
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