Kim Michael, Zhang Xiaokan
Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, NY, USA.
J Diabetes Clin Res. 2019;1(1):5-23. doi: 10.33696/diabetes.1.003.
Diabetes mellitus (DM), a complex metabolic disease, has become a global threat to human health worldwide. Over the past decades, an enormous amount of effort has been devoted to understand how microRNAs (miRNAs), a class of small non-coding RNA regulators of gene expression at the post-transcriptional level, are implicated in DM pathology. Growing evidence suggests that the expression signature of a specific set of miRNAs has been altered in the progression of DM. In the present review, we summarize the recent investigations on the miRNA profiles as novel DM biomarkers in clinical studies and in animal models, and highlight recent discoveries on the complex regulatory effect and functional role of miRNAs in DM.
糖尿病（DM）是一种复杂的代谢性疾病，已成为全球范围内对人类健康的一大威胁。在过去几十年里，人们付出了巨大努力来了解微小RNA（miRNA），这是一类在转录后水平调控基因表达的小型非编码RNA调节因子，是如何参与糖尿病病理过程的。越来越多的证据表明，在糖尿病进展过程中，特定一组miRNA的表达特征发生了改变。在本综述中，我们总结了临床研究和动物模型中有关miRNA谱作为新型糖尿病生物标志物的最新研究，并重点介绍了miRNA在糖尿病中的复杂调节作用和功能的最新发现。
