Ruiz-Gonzalez Cristofer, Cardona Diana, Rueda-Ruzafa Lola, Rodriguez-Arrastia Miguel, Ropero-Padilla Carmen, Roman Pablo
Torrecárdenas University Hospital, Almeria, Andalusia, 04009, Spain.
Research Group CTS-1114 Advances and Innovation in Health, University of Almeria, Almeria, Andalusia, 04120, Spain.
Probiotics Antimicrob Proteins. 2024 Jun 27. doi: 10.1007/s12602-024-10315-2.
As the population ages, cognitive decline becomes more common. Strategies targeting the gut-brain axis using probiotics are emerging to achieve improvements in neuropsychiatric and neurological disorders. However, the beneficial role of probiotics on brain function in healthy older adults remains unclear. Our aim was to evaluate a multi-species probiotic formulation as a therapeutic approach to reduce emotional and cognitive decline associated with aging in healthy adults. A randomized double-blind placebo-controlled crossover trial was conducted. The study involved a 10-week intervention where participants consumed the assigned probiotic product daily, followed by a 4-week washout period before the second condition started. Cognitive function was assessed using the Mini-Mental State Examination (MMSE) and the Psychological Experiments Construction Language Test Battery. At the emotional level, the Beck Depression Inventory (BDI) and the State-Trait Anxiety Inventory (STAI) were used. Thirty-three participants, recruited between July 2020 and April 2022, ingested a multispecies probiotic (Lactobacillus rhamnosus and Bifidobacterium lactis). After the intervention, noticeable enhancements were observed in cognitive function (mean difference 1.90, 95% CI 1.09 to 2.70, p < 0.005), memory (mean difference 4.60, 95% CI 2.91 to 6.29, p < 0.005) by MMSE and digit task, and depressive symptoms (mean difference 4.09, 95% CI 1.70 to 6.48, p < 0.005) by BDI. Furthermore, there were significant improvements observed in planning and problem-solving skills, selective attention, cognitive flexibility, impulsivity, and inhibitory ability. Probiotics administration improved cognitive and emotional function in older adults. Limited research supports this, requiring more scientific evidence for probiotics as an effective therapy for cognitive decline. This study has been prospectively registered at ClinicalTrials.gov (NCT04828421; 2020/July/17).
随着人口老龄化，认知能力下降变得越来越普遍。针对肠道-脑轴使用益生菌的策略正在兴起，以改善神经精神和神经系统疾病。然而，益生菌对健康老年人脑功能的有益作用仍不清楚。我们的目的是评估一种多菌种益生菌制剂作为一种治疗方法，以减少健康成年人与衰老相关的情绪和认知能力下降。进行了一项随机双盲安慰剂对照交叉试验。该研究包括为期10周的干预，参与者每天食用指定的益生菌产品，然后在第二种情况开始前有4周的洗脱期。使用简易精神状态检查表（MMSE）和心理实验构建语言测试电池评估认知功能。在情绪层面，使用贝克抑郁量表（BDI）和状态-特质焦虑量表（STAI）。2020年7月至2022年4月招募的33名参与者摄入了一种多菌种益生菌（鼠李糖乳杆菌和乳酸双歧杆菌）。干预后，通过MMSE和数字任务观察到认知功能（平均差异1.90，95%可信区间1.09至2.70，p<0.005）、记忆力（平均差异4.60，95%可信区间2.91至6.29，p<0.005）有显著提高，通过BDI观察到抑郁症状（平均差异4.09，95%可信区间1.70至6.48，p<0.005）有显著改善。此外，在计划和解决问题的能力、选择性注意力、认知灵活性、冲动性和抑制能力方面也观察到了显著改善。服用益生菌改善了老年人的认知和情绪功能。有限的研究支持这一点，需要更多科学证据证明益生菌是治疗认知能力下降的有效疗法。本研究已在ClinicalTrials.gov上进行前瞻性注册（NCT04828421；2020/7/17）。
