Mendes A M, Madon R J, Flint D J
J Endocrinol. 1985 Aug;106(2):225-31. doi: 10.1677/joe.0.1060225.
Cortisol implants in normal and diabetic rats reduced body weight, adiposity, insulin receptor concentration and both basal and insulin-stimulated rates of lipogenesis in isolated adipocytes, whilst insulin sensitivity was unchanged. In normal but not diabetic rats these changes were accompanied by increased serum glucose and insulin concentrations. In contrast, progesterone implants in normal and diabetic rats increased body weight gain, adiposity, insulin receptor concentration and both basal and insulin-stimulated rates of lipogenesis in adipose tissue, again without affecting insulin sensitivity. Progesterone did not affect serum insulin concentrations in normal or diabetic rats but accelerated the decline in serum glucose concentrations which occurred during an overnight fast in diabetic rats. The results suggest that cortisol inhibits lipogenesis in adipose tissue without affecting insulin sensitivity, cortisol reduces insulin binding in adipose tissue without a requirement for hyperinsulinaemia, which might itself indirectly lead to down-regulation of the insulin receptor, and in diabetic rats progesterone stimulates lipogenesis in adipose tissue without any increase in food intake or serum insulin concentrations suggesting that progesterone may have a direct anabolic role in adipose tissue.
在正常大鼠和糖尿病大鼠体内植入皮质醇会降低体重、肥胖程度、胰岛素受体浓度以及分离脂肪细胞中基础和胰岛素刺激的脂肪生成速率，而胰岛素敏感性未发生变化。在正常大鼠而非糖尿病大鼠中，这些变化伴随着血清葡萄糖和胰岛素浓度的升高。相比之下，在正常大鼠和糖尿病大鼠体内植入孕酮会增加体重增加、肥胖程度、胰岛素受体浓度以及脂肪组织中基础和胰岛素刺激的脂肪生成速率，同样不影响胰岛素敏感性。孕酮对正常或糖尿病大鼠的血清胰岛素浓度没有影响，但加速了糖尿病大鼠过夜禁食期间血清葡萄糖浓度的下降。结果表明，皮质醇抑制脂肪组织中的脂肪生成而不影响胰岛素敏感性，皮质醇降低脂肪组织中的胰岛素结合而无需高胰岛素血症，高胰岛素血症本身可能间接导致胰岛素受体下调，并且在糖尿病大鼠中，孕酮刺激脂肪组织中的脂肪生成而食物摄入量或血清胰岛素浓度没有任何增加，这表明孕酮可能在脂肪组织中具有直接的合成代谢作用。
