Fisher D A, Hunt S W, Hood L
J Exp Med. 1985 Aug 1;162(2):528-45. doi: 10.1084/jem.162.2.528.
We have determined the DNA sequence of a gene encoding a thymus leukemia (TL) antigen in the BALB/c mouse, and have more definitively mapped the cloned BALB/c Tla-region class I gene clusters. Analysis of the sequence shows that the Tla gene is less closely related to the H-2 genes than H-2 genes are to one another or to a Qa-2,3-region genes. The Tla gene, 17.3A, contains an apparent gene conversion. Comparison of the BALB/c Tla genes with those from C57BL shows that BALB/c has more Tla-region class I genes, and that one of the genes absent in C57BL is gene 17.3A.
我们已经确定了编码BALB/c小鼠胸腺白血病(TL)抗原的基因的DNA序列,并更明确地绘制了克隆的BALB/c Tla区域I类基因簇图谱。序列分析表明,Tla基因与H-2基因的亲缘关系不如H-2基因之间或与Qa-2、3区域基因的亲缘关系密切。Tla基因17.3A包含一个明显的基因转换。将BALB/c Tla基因与C57BL的Tla基因进行比较,结果表明BALB/c拥有更多的Tla区域I类基因,且C57BL中缺失的一个基因是17.3A基因。