来自Tla复合体的一个低多态性小鼠H-2 I类基因在多种细胞类型中表达。
A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types.
作者信息
Transy C, Nash S R, David-Watine B, Cochet M, Hunt S W, Hood L E, Kourilsky P
出版信息
J Exp Med. 1987 Aug 1;166(2):341-61. doi: 10.1084/jem.166.2.341.
Abstract
We have previously described the isolation of pH-2d-37, a cDNA clone that encodes a so far unknown, poorly polymorphic, class I surface molecule. We report here the isolation of the corresponding gene, its nucleotide sequence, and its localization in the Tla region of the murine MHC. Using a RNase mapping assay, we have confirmed that the second domain coding region of the 37 gene displays very limited polymorphism, and that the gene is transcribed in a broad variety of cell types, in contrast to the genes encoding the known Qa and TL antigens. Possible functions are discussed.
摘要
我们之前描述过pH - 2d - 37的分离，它是一个cDNA克隆，编码一种迄今未知、多态性低的I类表面分子。我们在此报告相应基因的分离、其核苷酸序列及其在小鼠MHC的Tla区域中的定位。使用核糖核酸酶图谱分析，我们证实37基因的第二个结构域编码区显示出非常有限的多态性，并且与编码已知Qa和TL抗原的基因不同，该基因在多种细胞类型中都有转录。文中还讨论了其可能的功能。
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