Jackson V P, Bendick P J
J Ultrasound Med. 1985 Aug;4(8):411-5. doi: 10.7863/jum.1985.4.8.411.
Duplex carotid sonography was performed on 254 asymptomatic patients over the age of 55, yielding 500 adequate vessel examinations. Overall, 19.8 per cent of vessels were normal, 27 per cent had mild disease (less than 30 per cent diameter stenosis), 23 per cent had 30-49 per cent stenosis, 18.8 per cent had 50-69 per cent stenosis, 8.6 per cent had severe stenosis of 70-99 per cent, and 2.8 per cent of vessels were occluded. Many of the patients eventually underwent major surgical procedures and there were no cases of operative or perioperative morbidity or mortality. Only one of 254 patients has had a stroke in the two-year study period. Arteriosclerotic disease is common in patients over 55 years of age, but, in this series, does not seem to be of clinical significance. This supports the view that invasive tests and carotid endarterectomy should be reserved for symptomatic patients. Duplex sonography is an excellent noninvasive method of evaluation and follow-up of asymptomatic patients, and long-term studies with this modality should help to determine the natural history and clinical significance of extracranial carotid arteriosclerotic disease.
对254名55岁以上的无症状患者进行了颈动脉双功超声检查，共获得500次充分的血管检查结果。总体而言，19.8%的血管正常，27%有轻度病变（直径狭窄小于30%），23%有30%至49%的狭窄，18.8%有50%至69%的狭窄，8.6%有70%至99%的严重狭窄，2.8%的血管闭塞。许多患者最终接受了大型外科手术，且无手术或围手术期发病或死亡病例。在两年的研究期内，254名患者中只有1人发生了中风。动脉硬化疾病在55岁以上的患者中很常见，但在本系列研究中，似乎没有临床意义。这支持了以下观点，即侵入性检查和颈动脉内膜切除术应仅用于有症状的患者。双功超声检查是评估和随访无症状患者的一种极好的非侵入性方法，采用这种方式进行的长期研究应有助于确定颅外颈动脉粥样硬化疾病的自然病程和临床意义。
