基于细胞器的癌症免疫治疗策略。

Organelle-based immunotherapy strategies for fighting against cancer.

机构信息

College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, P. R. China.

Laoshan Laboratory, Qingdao 266237, P. R. China.

出版信息

Chem Commun (Camb). 2024 Aug 1;60(63):8170-8185. doi: 10.1039/d4cc01594k.

DOI:10.1039/d4cc01594k

PMID:38979965

Abstract

Destruction of subcellular organelles can cause dysfunction and even death of cells to elicit immune responses. In this review, the characteristics and functions of important organelles are mainly summarized. Then, the intelligent immunotherapeutic strategies and suggestions based on influencing the organelles are further highlighted. This review will provide ideas for developing novel and effective immunotherapy strategies and advance the development of cancer immunotherapy.

摘要

细胞内细胞器的破坏可导致细胞功能障碍甚至死亡，从而引发免疫反应。在这篇综述中，主要总结了重要细胞器的特征和功能。然后，进一步强调了基于影响细胞器的智能免疫治疗策略和建议。这篇综述将为开发新的有效的免疫治疗策略提供思路，并推进癌症免疫治疗的发展。