Department of Obstetrics & Gynecology, School of Medicine, Social Determinants of Health Research Center, Gonabad University of Medical Sciences, Gonabad, Iran.
Department of Midwifery, School of Medicine, Social Determinants of Health Research Center, Gonabad University of Medical Sciences, Gonabad, Iran.
J Ovarian Res. 2024 Jul 12;17(1):144. doi: 10.1186/s13048-024-01460-x.
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive age and the most common cause of infertility due to anovulation. PCOS in adolescents is concerning. Nigella sativa is effective in improving gonadotropins and sex hormones. The current study was designed to investigate the effect of Nigella sativa supplementation on PCOS symptoms and their severity in adolescents.
The current randomized clinical trial was conducted on 114 adolescents with PCOS who were referred to gynecologist offices and clinics in Gonabad, Iran from March 2022 to March 2023. Participants were randomly allocated to the intervention (Nigella sativa 1000 mg/day) and control (10 mg/day medroxyprogesterone from the 14th day of the cycle for 10 nights) groups. The study duration was 16 weeks. Ovarian volume (measured by ultrasound), anthropometric and blood pressure; serum testosterone, dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S), luteinizing hormone (LH), hirsutism severity (Ferriman-Gallwey score) levels were evaluated before and after the study.
Data from 103 participants (control group = 53, intervention group = 50) were analyzed. The mean age of participants was 17.0 (Interquartile range [IQR]:2.0). The mean difference in hirsutism score changes (p < 0.001), right (p = 0.002), and left (p = 0.010) ovarian volume, serum LH (p < 0.001) and testosterone (p = 0.001) were significantly higher in the intervention group compared to the control group. The frequency of oligomenorrhea, menometrorrhagia, and amenorrhea, were significantly reduced after the study in the intervention group compared to the control group (ps < 0.001).
Short-term Nigella sativa supplementation may be effective in reducing ovarian volume and improving hormonal balance, and menstrual irregularities in adolescents with PCOS. Further research and long-term studies are warranted to validate the potential therapeutic effects of Nigella sativa in adolescents with PCOS.
IRCT20221017056209N1 Registration date: 2022-11-22.
多囊卵巢综合征（PCOS）是生殖年龄最常见的内分泌疾病，也是排卵障碍导致不孕的最常见原因。青少年多囊卵巢综合征令人担忧。黑种草子能有效改善促性腺激素和性激素。本研究旨在探讨黑种草子补充剂对青少年多囊卵巢综合征症状及其严重程度的影响。
本随机临床试验于 2022 年 3 月至 2023 年 3 月在伊朗贡巴德的妇科医生办公室和诊所对 114 名多囊卵巢综合征青少年进行，参与者被随机分配到干预组（黑种草子 1000 毫克/天）和对照组（从周期第 14 天开始每晚 10 毫克醋酸甲羟孕酮 10 天）。研究持续 16 周。卵巢体积（超声测量）、人体测量和血压；血清睾酮、脱氢表雄酮（DHEA）、硫酸脱氢表雄酮（DHEA-S）、黄体生成素（LH）、多毛症严重程度（Ferriman-Gallwey 评分）水平在研究前后进行评估。
对 103 名参与者（对照组 53 名，干预组 50 名）的数据进行了分析。参与者的平均年龄为 17.0（四分位距 [IQR]：2.0）。干预组的多毛症评分变化（p<0.001）、右侧（p=0.002）和左侧（p=0.010）卵巢体积、血清 LH（p<0.001）和睾酮（p=0.001）的平均值差异显著高于对照组。与对照组相比，干预组研究后月经稀发、月经过多和闭经的频率显著降低（p<0.001）。
短期黑种草子补充可能有助于减少卵巢体积，改善多囊卵巢综合征青少年的激素平衡和月经不规律。需要进一步研究和长期研究来验证黑种草子在多囊卵巢综合征青少年中的潜在治疗效果。
IRCT 注册号：IRCT20221017056209N1 注册日期：2022 年 11 月 22 日。
