Mahmoudian Azamsadat, Ashouri Akram, Mohammadzadeh Fatemeh, Rahmani Bilandi Roghaieh, Dashti Sareh, Bahri Narjes
Department of Obstetrics & Gynecology, School of Medicine, Reproductive Health and Population Research Center, Gonabad University of Medical Sciences, Gonabad, Iran.
Department of Midwifery, School of Medicine, Social Determinants of Health Research Center, Gonabad University of Medical Sciences, Gonabad, Iran.
J Ovarian Res. 2025 Mar 7;18(1):46. doi: 10.1186/s13048-025-01634-1.
Adolescence is a critical period for health, as conditions like polycystic ovarian syndrome (PCOS) can affect long-term outcomes, including diabetes and other non-communicable diseases in adulthood. This study evaluated the effects of Nigella sativa L. extract on glycemia among adolescents with PCOS.
This secondary analysis used data from a randomized controlled trial conducted between March 2022 and March 2023. One hundred sixteen adolescent girls aged 12-18 years with PCOS were randomized into two groups. The intervention group received 1000 mg/day of Nigella sativa extract for 16 weeks, while the control group received 10 mg/day of medroxyprogesterone for 10 days per menstrual cycle over the same period. Fasting plasma glucose (FPG) and one- and two-hour post-prandial glucose levels were measured at baseline and after the intervention.
103 completed the study (50 in the Nigella sativa group and 53 in the control group). At baseline, there were no significant differences in FPG (p = 0.294), though the control group had higher one-hour (p = 0.002) and two-hour (p = 0.006) post-prandial glucose levels. Post-intervention, significant interaction effects were observed for FPG (p = 0.004) and two-hour post-prandial glucose (p = 0.023), indicating more significant reductions in the Nigella sativa group compared to the control group.
Considering the observed effect of Nigella sativa supplementation on FPG and two-hour post-prandial glucose, it may offer a complementary approach to managing glycemia in adolescent PCOS. However, further research is warranted.
青春期是健康的关键时期，因为多囊卵巢综合征（PCOS）等病症会影响长期健康结果，包括成年期的糖尿病和其他非传染性疾病。本研究评估了黑种草提取物对患有PCOS的青少年血糖水平的影响。
本二次分析使用了2022年3月至2023年3月期间进行的一项随机对照试验的数据。116名年龄在12 - 18岁的患有PCOS的青春期女孩被随机分为两组。干预组每天服用1000毫克黑种草提取物，持续16周，而对照组在同一时期每个月经周期服用10毫克甲羟孕酮，持续10天。在基线期和干预后测量空腹血糖（FPG）以及餐后1小时和2小时的血糖水平。
103名参与者完成了研究（黑种草组50名，对照组53名）。在基线期，FPG无显著差异（p = 0.294），尽管对照组的餐后1小时（p = 0.002）和2小时（p = 0.006）血糖水平较高。干预后，FPG（p = 0.004）和餐后2小时血糖（p = 0.023）观察到显著的交互作用，表明与对照组相比，黑种草组的降低更为显著。
考虑到补充黑种草对FPG和餐后2小时血糖的观察效果，它可能为管理青少年PCOS患者的血糖提供一种补充方法。然而，仍需要进一步的研究。
