Liu Dingyu, Liu Baoling, He Zhenwen, Qiao Changhong, Luo Qin, Chen Xiangyu, Wang Xiaohu, Xiang Hua, Chen Jing, Zhang Pian, Huang Yuan, Wang Gang, Tan Chen, Cai Rujian
Key Laboratory of Livestock Disease Prevention of Guangdong Province, Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry Diseases, Ministry of Agriculture and Rural Affairs, Institute of Animal Health, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China.
College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
Animals (Basel). 2024 Jun 24;14(13):1861. doi: 10.3390/ani14131861.
The Hepatitis E virus (HEV) causes acute and chronic Hepatitis E and is a global public health concern. HEV genotypes 3 (HEV-3) and 4 (HEV-4) are common to humans and animals, and domestic pigs and wild boars have been identified as the main reservoirs. However, limited information is available on the status of HEV infection in pigs, particularly in the Guangdong Province, China. This study aimed to investigate the seroprevalence of HEV in pig farms within the Guangdong Province. A total of 1568 serum samples were collected from 25 farms and tested for anti-HEV IgG antibodies. Enzyme-linked immunosorbent assay (ELISA) results revealed that 57.53% (902/1568) of serum samples from 24 farms (24/25, 96%) were positive for anti-HEV IgG antibodies. Year, season, region, and age were all linked risk factors for HEV in Guangdong, with season and region showing more significant impacts. The results showing a high seroprevalence of HEV confirmed its circulation among domestic pigs in the Guangdong Province, China. The presence of this antibody indicates that HEV infection was or is present on farms, posing a risk of zoonotic transmission of HEV from pigs to exposed workers and from pork or organs to consumption.
戊型肝炎病毒（HEV）可引发急性和慢性戊型肝炎，是一个全球公共卫生问题。HEV 基因型 3（HEV-3）和 4（HEV-4）在人类和动物中都很常见，家猪和野猪已被确定为主要宿主。然而，关于猪中 HEV 感染状况的信息有限，尤其是在中国广东省。本研究旨在调查广东省猪场中 HEV 的血清流行率。共从 25 个猪场收集了 1568 份血清样本，并检测抗 HEV IgG 抗体。酶联免疫吸附测定（ELISA）结果显示，来自 24 个猪场（24/25，96%）的血清样本中有 57.53%（902/1568）抗 HEV IgG 抗体呈阳性。年份、季节、地区和年龄都是广东省 HEV 的相关风险因素，其中季节和地区的影响更为显著。结果显示 HEV 的血清流行率很高，证实了其在中国广东省家猪中的传播。这种抗体的存在表明猪场中存在或曾经存在 HEV 感染，这构成了 HEV 从猪向接触的工人以及从猪肉或器官向消费者进行人畜共患病传播的风险。
