Antimicrobial Resistance Laboratory, Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, India.
Antimicrobial Resistance Laboratory, Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, India.
Drug Discov Today. 2024 Aug;29(8):104099. doi: 10.1016/j.drudis.2024.104099. Epub 2024 Jul 11.
Photodynamic therapy (PDT) is a minimally invasive treatment showing promise against cancer and microbial infections. PDT targets tumor cells while sparing healthy tissue, reducing side effects. It induces immunogenic cell death, potentially stimulating antitumor immune responses and reducing cancer recurrence. In microbial treatment, PDT effectively combats bacteria, fungi and viruses. Combining PDT with chemotherapy, radiotherapy and immunotherapy enhances its efficacy. However, challenges such as tumor hypoxia, limited tissue penetration and phototoxicity necessitate ongoing research efforts to optimize PDT protocols and overcome limitations. Overall, PDT is versatile and continually advancing with refined protocols to improve its clinical utility against cancer and microbial infections.
光动力疗法（PDT）是一种有前途的微创治疗方法，可用于治疗癌症和微生物感染。PDT 靶向肿瘤细胞，同时保护健康组织，减少副作用。它诱导免疫原性细胞死亡，有可能刺激抗肿瘤免疫反应并降低癌症复发率。在微生物治疗方面，PDT 可有效对抗细菌、真菌和病毒。将 PDT 与化疗、放疗和免疫疗法相结合可提高其疗效。然而，肿瘤缺氧、组织穿透有限和光毒性等挑战需要持续的研究努力，以优化 PDT 方案并克服限制。总的来说，PDT 具有多功能性，并且随着协议的不断完善，其在癌症和微生物感染方面的临床应用也在不断推进。
