Brownlie J, Howard C J, Gourlay R N
J Hyg (Lond). 1979 Dec;83(3):501-5. doi: 10.1017/s0022172400026346.
The infusion of 10 microgram of endotoxin lipopolysaccharide from Escherichia coli into the mammary gland of four cows 16 h before inoculation with ureaplasmas did not prevent, or even diminish, the subsequent ureaplasmal mastitis. There was no reduction in the severity or duration of the inflammatory cell response in milk or in the clinical appearance of the resulting mastitis. Also, the excretion of ureaplasmas was not reduced. A similar experiment with Mycoplasma dispar in two cows demonstrated that endotoxin was again ineffective in preventing the mastitis. Furthermore, there was some indication that the proliferation and excretion of this mycoplasma was enhanced in endotoxin-treated quarters.
在给四头奶牛接种脲原体前16小时，向其乳腺内注入10微克来自大肠杆菌的内毒素脂多糖，这并未预防甚至减轻随后发生的脲原体性乳腺炎。牛奶中炎性细胞反应的严重程度或持续时间以及由此导致的乳腺炎的临床表现均未减轻。此外，脲原体的排泄也未减少。在两头奶牛身上进行的一项关于副猪支原体的类似实验表明，内毒素在预防乳腺炎方面同样无效。此外，有迹象表明，在经内毒素处理的乳腺中，这种支原体的增殖和排泄有所增强。
