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一名14岁免疫功能正常女性被诊断为冠状病毒NL63脑炎的有趣病例：病例报告及文献综述

An Interesting Case of Coronavirus NL63 Encephalitis Diagnosed in a 14-Year-Old Immunocompetent Female: A Case Report and Literature Review.

作者信息

Saeed Ahsan A, Helali Hadi, Alhammadi Moza

机构信息

Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, ARE.

Pediatrics, Al Jalila Children's Specialty Hospital, Dubai, ARE.

出版信息

Cureus. 2024 Jun 12;16(6):e62229. doi: 10.7759/cureus.62229. eCollection 2024 Jun.

DOI:10.7759/cureus.62229
PMID:39006646
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11244723/
Abstract

Human coronavirus NL63 (HCoV-NL63) belongs to the human coronavirus family but is distinct from other common coronaviruses such as HCoV-043, HCoV-229E, and SARS-CoV-1 and SARS-CoV-2 viruses. It causes a mild upper respiratory tract infection, affecting children and adults. The usual symptoms associated with the HCoV-NL63 infection are vomiting, a runny nose, and a sore throat. In vivo, HCoV-NL63 showed neurotropism as it can be detected in the CSF, through which it disseminates into the brain and the spinal column. Herein, we describe the case of a 14-year-old female patient who initially presented with disorientation and a drop in consciousness level and was admitted as a case of encephalitis to the pediatric intensive care unit.

摘要

人冠状病毒NL63（HCoV-NL63）属于人冠状病毒家族，但与其他常见冠状病毒不同，如HCoV-043、HCoV-229E以及SARS-CoV-1和SARS-CoV-2病毒。它会引起轻度上呼吸道感染，影响儿童和成人。与HCoV-NL63感染相关的常见症状是呕吐、流鼻涕和喉咙痛。在体内，HCoV-NL63表现出嗜神经性，因为它可以在脑脊液中被检测到，并通过脑脊液扩散到大脑和脊柱。在此，我们描述了一名14岁女性患者的病例，该患者最初出现定向障碍和意识水平下降，作为脑炎病例被收入儿科重症监护病房。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/906c/11244723/7463de27ceb6/cureus-0016-00000062229-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/906c/11244723/53fb9ac91e29/cureus-0016-00000062229-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/906c/11244723/7463de27ceb6/cureus-0016-00000062229-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/906c/11244723/53fb9ac91e29/cureus-0016-00000062229-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/906c/11244723/7463de27ceb6/cureus-0016-00000062229-i02.jpg

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Rev Med Virol. 2022 Mar;32(2):e2282. doi: 10.1002/rmv.2282. Epub 2021 Aug 2.
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