Department of Physiology, University of California Los Angeles, Los Angeles, CA, USA.
Adv Neurobiol. 2024;38:67-78. doi: 10.1007/978-3-031-62983-9_5.
The medial prefrontal cortex (mPFC) plays a critical role in recalling recent and remote fearful memories. Modern neuroscience techniques, such as projection-specific circuit manipulation and activity-dependent labeling, have illuminated how mPFC memory ensembles are reorganized over time. This chapter discusses the implications of new findings for traditional theories of memory, such as the systems consolidation theory and theories of memory engrams. It also examines the specific contributions of mPFC subregions, like the prelimbic and infralimbic cortices, in fear memory, highlighting how their distinct connections influence memory recall. Further, it elaborates on the cellular and molecular changes within the mPFC that support memory persistence and how these are influenced by interactions with the hippocampus. Ultimately, this chapter provides insights into how lasting memories are dynamically encoded in prefrontal circuits, arguing for a key role of memory ensembles that extend beyond strict definitions of the engram.
内侧前额叶皮层（mPFC）在回忆近期和远期恐惧记忆方面起着关键作用。现代神经科学技术，如特定投射回路的操作和依赖于活性的标记，已经阐明了 mPFC 记忆集合是如何随时间重新组织的。本章讨论了新发现对记忆传统理论的影响，如系统巩固理论和记忆印痕理论。它还检查了 mPFC 子区域（如前扣带回和下边缘皮层）在恐惧记忆中的特定贡献，强调了它们不同的连接如何影响记忆回忆。此外，它详细阐述了支持记忆持久性的 mPFC 内的细胞和分子变化，以及这些变化如何受到与海马体相互作用的影响。最终，本章提供了关于持久记忆如何在额前回路中动态编码的深入了解，支持了记忆集合的关键作用，超越了对印痕的严格定义。
