College of Food Science & Nutritional Engineering, China Agricultural University, Beijing Key Laboratory of Functional Food from Plant Resources, Beijing, PR China.
College of Food Science, Northeast Agricultural University, Haerbin, Heilongjiang Province, PR China.
Biosens Bioelectron. 2024 Oct 15;262:116567. doi: 10.1016/j.bios.2024.116567. Epub 2024 Jul 11.
Food safety and human health remain significant concerns in the food industry. Detecting food contaminants and diagnosing diseases are critical aspects. Ferritin, an iron storage protein widely found in nature, offers unique advantages. Its hollow protein nanocage structure, distinct interfaces, hydrophobic or hydrophilic channels, and B-C loop regions recognized by transferrin receptor 1 make ferritin versatile for detecting heavy metals, free radicals, and bioimaging both in vitro and in vivo. This review summarizes ferritin's general characteristics, its specific properties as biosensors, and its applications in food safety and in vivo imaging. It emphasizes not only ferritin's role in detecting heavy metals like mercury and chemical hazards but also its potential in early diagnosing chronic diseases such as tumors, macrophages, and kidney diseases. Further research into ferritin promises advancements in enhancing food safety and improving human health diagnostics.
食品安全和人类健康仍然是食品工业中的重要关注点。检测食品污染物和诊断疾病是至关重要的方面。铁蛋白是一种在自然界中广泛存在的铁储存蛋白，具有独特的优势。其空心蛋白纳米笼结构、独特的界面、疏水或亲水通道以及转铁蛋白受体 1 识别的 B-C 环区域，使铁蛋白在体外和体内检测重金属、自由基和生物成像方面具有多功能性。本综述总结了铁蛋白的一般特征、作为生物传感器的特定性质及其在食品安全和体内成像中的应用。它不仅强调了铁蛋白在检测汞和化学危害等重金属方面的作用，还强调了它在早期诊断肿瘤、巨噬细胞和肾脏疾病等慢性疾病方面的潜力。对铁蛋白的进一步研究有望提高食品安全水平并改善人类健康诊断。
