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Active immunization of NMRI mice against Serratia marcescens.

作者信息

Traub W H, Spohr M, Bauer D

出版信息

Zentralbl Bakteriol Mikrobiol Hyg A. 1985 May;259(3):410-25. doi: 10.1016/s0176-6724(85)80043-2.

DOI:10.1016/s0176-6724(85)80043-2
PMID:3901614
Abstract

Phenol-hot water lipopolysaccharide (LPS) extracts of Serratia marcescens strains CDC O3:H1, CDC O6:H3, NEW CDC O14:H12, and SH 186 (serotype O6/O14:H12) significantly protected NMRI mice against intraperitoneal challenge with the more mouse virulent homologous strains; overall, there was moderate cross-protection against the minority of heterologous challenge strains. Trichloroacetic acid LPS extracts and K-antigen extracts of strains NEW CDC O14:H12 and SH 186 also proved protective antigens. The purified metalloproteases of strains SH 186 and SF 178 (serotype O6/O14:H12) effected active murine immunization. Neither active nor passive immunization of NMRI mice with E. coli Rc mutant J5 afforded significant protection against various challenge strains of S. marcescens.

摘要

相似文献

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Active immunization of NMRI mice against Serratia marcescens.
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