Department of Otolaryngology, Head and Neck surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Biomater Sci. 2024 Aug 6;12(16):4136-4154. doi: 10.1039/d4bm00446a.
Hydrogen therapy, leveraging its selective attenuation of hydroxyl radicals (˙OH) and ONOO, has emerged as a pivotal pathophysiological modulator with antioxidant, anti-inflammatory, and antiapoptotic attributes. Hydrogen therapy has been extensively studied both preclinically and clinically, especially in diseases with an inflammatory nature. Despite the substantial progress, challenges persist in achieving high hydrogen concentrations in target lesions, especially in cancer treatment. A notable breakthrough lies in water/acid reactive materials, offering enhanced hydrogen generation and sustained release potential. However, limitations include hydrogen termination upon material depletion and reduced bioavailability at targeted lesions. To overcome these challenges, catalytic materials like photocatalytic and sonocatalytic materials have surfaced as promising solutions. With enhanced permeability and retention effects, these materials exhibit targeted delivery and sustained stimuli-reactive hydrogen release. The future of hydrogen therapy hinges on continuous exploration and modification of catalytic materials. Researchers are urged to prioritize improved catalytic efficiency, enhanced lesion targeting effects, and heightened biosafety and biocompatibility in future development.
氢气治疗利用其对羟自由基（˙OH）和过氧亚硝酸盐（ONOO）的选择性衰减作用，成为一种关键的病理生理学调节剂，具有抗氧化、抗炎和抗细胞凋亡的特性。氢气治疗在临床前和临床研究中都得到了广泛的研究，特别是在具有炎症性质的疾病中。尽管取得了重大进展，但在目标病变中实现高浓度氢气仍然存在挑战，特别是在癌症治疗中。一个显著的突破在于水/酸反应性材料，提供了增强的氢气生成和持续释放潜力。然而，这些材料存在的局限性包括材料耗尽时氢气的终止和目标病变部位生物利用度的降低。为了克服这些挑战，像光催化和声催化材料这样的催化材料已经成为有前途的解决方案。这些材料具有增强的通透性和保留效应，表现出靶向递药和持续的刺激反应性氢气释放。氢气治疗的未来取决于对催化材料的持续探索和改进。研究人员被敦促在未来的发展中优先考虑提高催化效率、增强病变靶向效果以及提高生物安全性和生物相容性。
