Department of Mathematics, Government College University, Faisalabad, 38000, Pakistan.
Department of Computer Science and Mathematics, Lebanese American University, 11022801, Beirut, Lebanon.
Sci Rep. 2024 Jul 23;14(1):16922. doi: 10.1038/s41598-024-65329-1.
In this article, we considered a nonlinear compartmental mathematical model that assesses the effect of treatment on the dynamics of HIV/AIDS and pneumonia (H/A-P) co-infection in a human population at different infection stages. Understanding the complexities of co-dynamics is now critically necessary as a consequence. The aim of this research is to construct a co-infection model of H/A-P in the context of fractional calculus operators, white noise and probability density functions, employing a rigorous biological investigation. By exhibiting that the system possesses non-negative and bounded global outcomes, it is shown that the approach is both mathematically and biologically practicable. The required conditions are derived, guaranteeing the eradication of the infection. Furthermore, adequate prerequisites are established, and the configuration is tested for the existence of an ergodic stationary distribution. For discovering the system's long-term behavior, a deterministic-probabilistic technique for modeling is designed and operated in MATLAB. By employing an extensive review, we hope that the previously mentioned approach improves and leads to mitigating the two diseases and their co-infections by examining a variety of behavioral trends, such as transitions to unpredictable procedures. In addition, the piecewise differential strategies are being outlined as having promising potential for scholars in a range of contexts because they empower them to include particular characteristics across multiple time frame phases. Such formulas can be strengthened via classical techniques, power law, exponential decay, generalized Mittag-Leffler kernels, probability density functions and random procedures. Furthermore, we get an accurate description of the probability density function encircling a quasi-equilibrium point if the effect of H/A-P minimizes the propagation of the co-dynamics. Consequently, scholars can obtain better outcomes when analyzing facts using random perturbations by implementing these strategies for challenging issues. Random perturbations in H/A-P co-infection are crucial in controlling the spread of an epidemic whenever the suggested circulation is steady and the amount of infection eliminated is closely correlated with the random perturbation level.
在本文中,我们考虑了一个非线性房室数学模型,该模型评估了治疗对不同感染阶段人群中 HIV/AIDS 和肺炎(H/A-P)合并感染动态的影响。因此,现在迫切需要了解合并感染的复杂性。本研究的目的是在分数阶微积分算子、白噪声和概率密度函数的背景下构建 H/A-P 合并感染模型,采用严格的生物学研究。通过证明系统具有非负和有界的全局结果,表明该方法在数学和生物学上都是可行的。得出了所需的条件,保证了感染的消除。此外,建立了充分的前提条件,并对该配置进行了遍历平稳分布存在性的检验。为了发现系统的长期行为,设计并在 MATLAB 中运行了用于建模的确定性-概率技术。通过广泛的综述,我们希望所提到的方法能够改进并减轻这两种疾病及其合并感染,通过研究各种行为趋势,例如向不可预测过程的转变。此外,分段微分策略被概述为具有广泛的应用潜力,因为它们使学者能够在多个时间框架阶段纳入特定特征。通过经典技术、幂律、指数衰减、广义 Mittag-Leffler 核、概率密度函数和随机过程,可以增强这些公式。此外,如果 H/A-P 的影响最小化了合并动态的传播,我们可以获得围绕准平衡点的概率密度函数的准确描述。因此,学者们可以通过实施这些策略来解决具有挑战性的问题,在使用随机扰动分析事实时获得更好的结果。在建议的循环稳定且消除的感染量与随机扰动水平密切相关的情况下,随机扰动在 H/A-P 合并感染中对于控制流行病的传播至关重要。
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