Thamrongwatwongsa Jiralapat, Chusrisom Jittraporn, Katemala Kittiphat, Tantasirin Siranat, Jumnongjit Proudphat, Nateerom Pascha, Sonjaroon Weerasin, Tongkok Pattama, Pichaiyotinkul Panutchaya, Paemanee Atchara, T-Thienprasert Nattanan Panjaworayan, Phonphoem Wannarat
Department of Biochemistry, Faculty of Science, Kasetsart University, Bangkok, Thailand.
Kasetsart Agricultural and Agro-Industrial Product Improvement Institute, Kasetsart University, Bangkok, Thailand.
Heliyon. 2024 Jun 26;10(13):e33330. doi: 10.1016/j.heliyon.2024.e33330. eCollection 2024 Jul 15.
Blume, a plant of significant pharmacological and cultural importance in its native regions, has been the subject of traditional medicinal use. This study, however, delves deeper into the unique attributes of aerial part and root extracts, particularly their phytochemical content, antioxidant potential, antibacterial activity, and anticancer properties against human skin cancer cells. The results unveiled a promising aspect-higher flavonoid and phenolic compound levels in the aerial part compared to the root extracts. Both aerial part and root extracts demonstrated significant antioxidant activities, as evidenced by their ability to scavenge DPPH radicals and reduce ferric ions in the FRAP assay. Moreover, the ethanolic extract derived from aerial parts showed promising antibacterial activity against both gram-positive and gram-negative bacteria, hinting at its potential therapeutic efficacy. Notably, this extract also demonstrates a capacity to impede the viability of human skin cancer cells (A375). Collectively, these results demonstrated the potential applications of the aerial part extracts. Further investigation is imperative to elucidate the intricate molecular mechanisms underpinning these diverse effects, thereby contributing to a deeper understanding of the pharmacological potential of and its prospective applications in medicine and beyond.
布鲁姆（Blume）是一种在其原生地区具有重要药理和文化意义的植物，一直是传统药用的对象。然而，本研究更深入地探究了地上部分和根部提取物的独特特性，特别是它们的植物化学成分、抗氧化潜力、抗菌活性以及对人类皮肤癌细胞的抗癌特性。结果揭示了一个有前景的方面——地上部分提取物中的黄酮类和酚类化合物含量高于根部提取物。地上部分和根部提取物均表现出显著的抗氧化活性，在DPPH自由基清除实验和FRAP实验中还原铁离子的能力证明了这一点。此外，地上部分的乙醇提取物对革兰氏阳性菌和革兰氏阴性菌均表现出有前景的抗菌活性，暗示了其潜在的治疗效果。值得注意的是，这种提取物还表现出抑制人类皮肤癌细胞（A375）活力的能力。总体而言，这些结果证明了地上部分提取物的潜在应用。进一步的研究势在必行，以阐明支撑这些多样效应的复杂分子机制，从而有助于更深入地理解布鲁姆的药理潜力及其在医学及其他领域的潜在应用。
