2'-岩藻糖基乳糖和乳糖-N-新四糖溶液作为感染根管冲洗剂的评估：一项体外研究
Assessment of 2'-Fucosyllactose and Lacto-N-Neotetraose Solution as an Irrigant in -Infected Root Canals: An In Vitro Study.
作者信息
Puleio Francesco, Pirri Rosario, Tosco Vincenzo, Lizio Angelo Sergio, Tripodi Paola, La Spina Isabella, La Fauci Vincenza, Squeri Raffaele
机构信息
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Messina University, 98100 Messina, Italy.
Department of Clinical Sciences and Stomatology (DISCO), Università Politecnica delle Marche, 60126 Ancona, Italy.
出版信息
Clin Pract. 2024 Jul 10;14(4):1348-1356. doi: 10.3390/clinpract14040108.
BACKGROUND
Given the lack of an ideal endodontic irrigant on the market, this study evaluates the antimicrobial potential of a formulated solution of 2'-fucosyllactose and lacto-N-neotetraose against within infected root canals, and explores any associated impacts related to the duration of irrigation.
METHODS
32 single-rooted teeth extracted for periodontal reasons were infected with , and subsequently subjected to endodontic treatment with two different irrigation systems: sodium hypochlorite or a solution of 2'-fucosyllactose and lacto-N-neotetraose. These samples were then incubated in sterile culture media at 37 °C to observe microbial activity through turbidity. The culture broth of each individual sample was assessed as positive or negative by observing the turbidity or lack of turbidity in the culture at the time of evaluation.
RESULTS
the analysis of the results obtained from the comparison of groups irrigated with sodium hypochlorite or a solution of 2'-fucosyllactose and lacto-N-neotetraose demonstrates that the case solution has no bactericidal effect against inoculated in the endodontic system.
CONCLUSIONS
the HMOs used in this study do not have a bactericidal effect on inoculated in an endodontic system.
背景
鉴于市场上缺乏理想的牙髓冲洗剂，本研究评估了2'-岩藻糖基乳糖和乳糖-N-新四糖配方溶液对感染根管内[具体细菌名称未给出]的抗菌潜力，并探讨了与冲洗持续时间相关的任何影响。
方法
32颗因牙周原因拔除的单根牙感染了[具体细菌名称未给出]，随后用两种不同的冲洗系统进行根管治疗：次氯酸钠或2'-岩藻糖基乳糖和乳糖-N-新四糖溶液。然后将这些样本在37°C的无菌培养基中培养，通过浊度观察微生物活性。通过在评估时观察培养物中的浊度或无浊度，将每个单独样本的培养液评估为阳性或阴性。
结果
对用次氯酸钠或2'-岩藻糖基乳糖和乳糖-N-新四糖溶液冲洗的组进行比较所获得结果的分析表明，该配方溶液对根管系统中接种的[具体细菌名称未给出]没有杀菌作用。
结论
本研究中使用的人乳寡糖对根管系统中接种的[具体细菌名称未给出]没有杀菌作用。
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