Royds J A, Variend S, Timperley W R, Taylor C B
J Clin Pathol. 1985 Nov;38(11):1258-60. doi: 10.1136/jcp.38.11.1258.
A comparative study of beta enolase and myoglobin as markers of muscle differentiation in rhabdomyosarcoma was carried out, using an immunoperoxidase peroxidase antiperoxidase technique. Material from 26 cases of childhood rhabdomyosarcoma was studied and subdivided into embryonal and alveolar types. Positive cytoplasmic staining for beta enolase was seen in 85% of tumours studied (91% alveolar, 79% embryonal), whereas positive staining for myoglobin was detected in only 69% of tumours (82% alveolar, 64% embryonal). beta Enolase and myoglobin are useful in the histological diagnosis of rhabdomyosarcoma, and of the two, beta enolase seems to be the more sensitive.
采用免疫过氧化物酶-抗过氧化物酶技术，对横纹肌肉瘤中作为肌肉分化标志物的β烯醇化酶和肌红蛋白进行了一项对比研究。对26例儿童横纹肌肉瘤的材料进行了研究，并将其细分为胚胎型和肺泡型。在所研究的肿瘤中，85%可见β烯醇化酶阳性细胞质染色（肺泡型为91%，胚胎型为79%），而仅在69%的肿瘤中检测到肌红蛋白阳性染色（肺泡型为82%，胚胎型为64%）。β烯醇化酶和肌红蛋白在横纹肌肉瘤的组织学诊断中有用，且两者中β烯醇化酶似乎更敏感。
