Watkins I D, Tobin J O, Dennis P J, Brown W, Newnham R, Kurtz J B
J Hyg (Lond). 1985 Oct;95(2):211-6. doi: 10.1017/s0022172400062641.
A panel of 10 monoclonal antibodies was used to subgroup 326 strains of Legionella pneumophila serogroup 1. All but two strains could be classified into three major subgroups named after their representative strains Pontiac 1, Olda and Bellingham 1. Of the 50 isolates from patients, 44 representing 32 separate incidents were of the Pontiac subgroup. This subgroup was also found in 16 of 18 buildings epidemiologically associated with Legionnaires' Disease. In contrast, strains of the Olda subgroup predominated in buildings where no infections had occurred. In 9 of the 11 incidents where isolates were available from at least one patient as well as from the suspected environmental source, the monoclonal antibody reaction patterns of strains from patients were identical to those of one or more of their environmental counterparts.
使用一组10种单克隆抗体对326株嗜肺军团菌血清1型进行亚群分类。除两株外，所有菌株均可分为三个主要亚群，以其代表性菌株庞蒂亚克1型、奥尔达型和贝灵汉姆1型命名。在从患者分离出的50株菌株中，代表32起独立事件的44株属于庞蒂亚克亚群。在与军团病有流行病学关联的18栋建筑物中的16栋中也发现了该亚群。相比之下，奥尔达亚群的菌株在未发生感染的建筑物中占主导地位。在11起事件中的9起中，从至少一名患者以及疑似环境来源分离出了菌株，患者菌株的单克隆抗体反应模式与其一个或多个环境对应菌株的反应模式相同。
