Castellani Pastoris M, McIntyre M, Goldoni P
Bacteriology and Medical Mycology, Istituto Superiore di Sanità, Rome, Italy.
Epidemiol Infect. 1990 Aug;105(1):169-74. doi: 10.1017/s0950268800047750.
The Oxford panel of monoclonal antibodies was used to subtype 83 strains of Legionella pneumophila serogroup 1 of human and environmental origin. The International panel was also used to subtype 50 of them. All the 18 patients' isolates were of the Pontiac subgroup, and 40/43 of the environmental strains of the Pontiac subgroup were associated with human infection. The remaining environmental strains were subgroups Olda (15 strains), Camperdown (5 strains), and Bellingham (2 strains). The Philadelphia subgroup was the commonest among the environmental strains tested with the international MABs panel. This study confirms previous findings that L. pneumophila serogroup 1 isolates with the Pontiac (Oxford panel) or MAB-2 (international panel) reacting antigen marker seem to be more virulent than the other subgroups.
采用牛津单克隆抗体组对83株来源于人类和环境的嗜肺军团菌血清1型菌株进行亚型分类。同时也采用国际抗体组对其中50株进行亚型分类。所有18株患者分离株均属于庞蒂亚克亚群，43株环境菌株中有40株庞蒂亚克亚群菌株与人类感染有关。其余环境菌株为奥尔达亚群（15株）、坎珀敦亚群（5株）和贝灵汉亚群（2株）。在用国际单克隆抗体组检测的环境菌株中，费城亚群最为常见。本研究证实了先前的发现，即带有庞蒂亚克（牛津抗体组）或MAB - 2（国际抗体组）反应性抗原标记的嗜肺军团菌血清1型分离株似乎比其他亚群更具毒性。
