利用单克隆抗体开发嗜肺军团菌1血清型的标准化亚群分类方案。
Development of a standardized subgrouping scheme for Legionella pneumophila serogroup 1 using monoclonal antibodies.
作者信息
Joly J R, McKinney R M, Tobin J O, Bibb W F, Watkins I D, Ramsay D
出版信息
J Clin Microbiol. 1986 Apr;23(4):768-71. doi: 10.1128/jcm.23.4.768-771.1986.
Abstract
A panel of monoclonal antibodies to Legionella pneumophila serogroup 1 and a subclassification scheme were developed in a collaborative project among three laboratories. The seven most useful monoclonal antibodies were selected from three previously developed panels on the basis of indirect fluorescent antibody patterns with 83 strains of L. pneumophila serogroup 1 that were obtained from widely distributed geographic locations. The isolates were divided into 10 major subgroups on the basis of reactivity patterns that can be readily reproduced in any laboratory and are not subject to major inconsistencies of interpretation of staining intensity. A standard protocol for the indirect fluorescent antibody procedure was also developed.
摘要
在三个实验室的合作项目中，开发了一组针对嗜肺军团菌血清1型的单克隆抗体和一种亚分类方案。根据从广泛分布的地理位置获得的83株嗜肺军团菌血清1型菌株的间接荧光抗体模式，从之前开发的三个抗体组中挑选出了七种最有用的单克隆抗体。这些分离株根据反应模式被分为10个主要亚组，该反应模式在任何实验室都能轻松重现，且不存在染色强度解释上的重大不一致。还制定了间接荧光抗体程序的标准方案。
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