科威特分离出的肠道病原体对甲氧苄啶的可转移性耐药性。
Transferable resistance to trimethoprim in enteric pathogens isolated in Kuwait.
作者信息
Chugh T D
出版信息
J Hyg (Lond). 1985 Oct;95(2):391-5. doi: 10.1017/s0022172400062811.
Abstract
Trimethoprim resistance was seen in 14.8% of 500 strains of salmonella, 43.1% of 153 strains of shigella and 59% of 27 strains of Escherichia coli isolated from stools of patients with diarrhoea. Strains with a high level of trimethoprim resistance (MIC of much greater than 512 micrograms) were subjected to conjugal transfer. Trimethoprim resistance was plasmid-mediated in all of 42 strains of shigella and 12 strains of E. coli examined. However, 2 of the 47 strains of salmonella could not transfer their trimethoprim resistance either directly or by mobilization with the transfer factors X and delta both at 37 and 25 degrees C overnight incubation.
摘要
从腹泻患者粪便中分离出的500株沙门氏菌中，14.8%出现甲氧苄啶耐药；153株志贺氏菌中，43.1%出现耐药；27株大肠杆菌中，59%出现耐药。对甲氧苄啶高度耐药（最低抑菌浓度远高于512微克）的菌株进行接合转移试验。在检测的所有42株志贺氏菌和12株大肠杆菌中，甲氧苄啶耐药是由质粒介导的。然而，47株沙门氏菌中的2株，无论在37℃还是25℃过夜培养条件下，都不能直接或通过转移因子X和δ介导转移其甲氧苄啶耐药性。
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