Gross R J, Rowe B, Cheasty T, Thomas L V
Br Med J (Clin Res Ed). 1981 Aug 29;283(6291):575-6. doi: 10.1136/bmj.283.6291.575.
Two thousand three hundred and seventy strains of Shigella dysenteriae, Sh flexneri, and Sh boydii isolated in England and Wales from 1974 to 1978 were tested for resistance to 12 antimicrobial drugs. Eighty per cent of strains were resistant to one or more drugs, with sulphonamide resistance occurring most frequently. Resistance to streptomycin, tetracycline, ampicillin, and chloramphenicol increased during the period, as did the incidence of multiple resistance. Most infections due to Sh dysenteriae, Sh flexneri, and Sh boydii are acquired abroad, and the increasing incidence of drug resistance among these organisms contrasts with the decreasing incidence of resistance among the indigenous Sh sonnei. These findings may indicate the need for better control of antibiotic use, particularly in developing countries.
对1974年至1978年在英格兰和威尔士分离出的2370株痢疾志贺氏菌、福氏志贺氏菌和鲍氏志贺氏菌进行了12种抗菌药物的耐药性测试。80%的菌株对一种或多种药物耐药，其中磺胺耐药最为常见。在此期间，对链霉素、四环素、氨苄青霉素和氯霉素的耐药性增加，多重耐药的发生率也增加。大多数由痢疾志贺氏菌、福氏志贺氏菌和鲍氏志贺氏菌引起的感染是在国外获得的，这些微生物中耐药性发生率的增加与本土宋内志贺氏菌耐药性发生率的下降形成对比。这些发现可能表明需要更好地控制抗生素的使用，特别是在发展中国家。
