Department of Economic and Medical Informatics, University of Lodz, 90-214 Lodz, Poland.
Department of Allergology and Respiratory Rehabilitation, Medical University of Lodz, 90-725 Lodz, Poland.
Int J Mol Sci. 2024 Jul 18;25(14):7843. doi: 10.3390/ijms25147843.
The genus , mainly , has emerged as a valuable source of bioactive compounds with potential neuroprotective properties. This review explores the antioxidant, anti-inflammatory, and neuroregenerative effects of -derived compounds and their implications for brain health and cognitive function. In vitro studies have demonstrated the ability of extracts to mitigate oxidative stress, modulate inflammatory responses, and promote neural stem cell proliferation and differentiation. In vivo studies using animal models of neurodegenerative diseases, such as Alzheimer's and Parkinson's, have shown that compounds can improve cognitive function, motor performance, and neuronal survival while attenuating neuroinflammation and oxidative damage. The neuroprotective effects of are primarily attributed to its rich content of polyphenols, particularly anthocyanins, which exert their benefits through multiple mechanisms, including the modulation of signaling pathways involved in inflammation, apoptosis, mitochondrial function, and oxidative stress. Furthermore, the potential of as a functional food ingredient is discussed, highlighting its application in various food products and the challenges associated with the stability and bioavailability of its bioactive compounds. This review provides a comprehensive overview of the current state of research on the neuroprotective potential of and its derivatives, offering valuable insights for the development of dietary strategies to promote brain health and prevent age-related cognitive decline.
该属植物主要作为具有潜在神经保护特性的生物活性化合物的有价值来源而出现。本综述探讨了 - 衍生化合物的抗氧化、抗炎和神经再生作用及其对大脑健康和认知功能的影响。体外研究表明,提取物能够减轻氧化应激、调节炎症反应、促进神经干细胞增殖和分化。使用阿尔茨海默病和帕金森病等神经退行性疾病的动物模型进行的体内研究表明,化合物可以改善认知功能、运动性能和神经元存活,同时减轻神经炎症和氧化损伤。 的神经保护作用主要归因于其丰富的多酚含量,特别是花色苷,其通过多种机制发挥作用,包括调节炎症、细胞凋亡、线粒体功能和氧化应激相关信号通路。此外,还讨论了 作为功能性食品成分的潜力,强调了其在各种食品产品中的应用以及其生物活性化合物的稳定性和生物利用度相关的挑战。本综述提供了对 及其衍生物的神经保护潜力的研究现状的全面概述,为开发促进大脑健康和预防与年龄相关的认知衰退的饮食策略提供了有价值的见解。