Clarkson T B, Koritnik D R, Weingand K W, Miller L C
Metabolism. 1985 Dec;34(12 Suppl 1):51-9. doi: 10.1016/s0026-0495(85)80010-x.
Nonhuman primates have been used for many years to investigate the pathogenesis and progression of atherosclerosis. The use of these animal models has resulted in a better understanding of the risk factors associated with atherosclerosis. Nonhuman primates that have consumed an atherogenic diet for several years develop lesions that are comparable to those found in human beings. Diabetes, both spontaneous and chemically induced, has been described in a number of nonhuman primate species. These diabetic models may be used to understand the accelerated progression and vascular complications of atherosclerosis in diabetic human beings.
多年来，非人灵长类动物一直被用于研究动脉粥样硬化的发病机制和进展。使用这些动物模型使人们对与动脉粥样硬化相关的危险因素有了更好的理解。食用致动脉粥样硬化饮食数年的非人灵长类动物会出现与人类相似的病变。许多非人灵长类物种都有自发性和化学诱导性糖尿病的报道。这些糖尿病模型可用于了解糖尿病患者动脉粥样硬化的加速进展和血管并发症。
