Wilson C L, Burge S M, Dean D, Dawber R P
Department of Dermatology, Slade Hospital, Oxford, U.K.
Br J Dermatol. 1992 Apr;126(4):307-14. doi: 10.1111/j.1365-2133.1992.tb00670.x.
The clinicopathological features of the scarring alopecia of discoid lupus erythematosus (DLE) were studied. Scarring alopecia was present in 34% of 89 patients with DLE and was associated with a prolonged disease course. More than half these patients had scalp involvement at the onset of the disease. There was a significant reduction in size of sebaceous glands in affected scalp. Perifollicular lymphocytic inflammation was maximal around the mid-follicle at the level of the sebaceous gland, which seems to be an important functional level in the follicle. There are changes in the expression of the matrix molecules, the proteoglycans, in the connective tissue sheath and the keratin intermediate filaments in the outer root sheath cells at this level in normal scalp and in diseased scalp. Loss of a population of mid-follicular stem cells may be important in the pathogenesis of scarring alopecia in DLE.
对盘状红斑狼疮（DLE）瘢痕性脱发的临床病理特征进行了研究。89例DLE患者中，34%出现瘢痕性脱发，且与病程延长有关。这些患者中超过一半在疾病初发时头皮就受累。受累头皮的皮脂腺大小显著减小。毛囊周围淋巴细胞炎症在皮脂腺水平的毛囊中部最为明显，这似乎是毛囊中的一个重要功能水平。在正常头皮和患病头皮的该水平，结缔组织鞘中的基质分子、蛋白聚糖以及外根鞘细胞中的角蛋白中间丝的表达均有变化。毛囊中部干细胞群的丧失可能在DLE瘢痕性脱发的发病机制中起重要作用。
