Prasetyo Endry Nugroho, Rokana Efi, Baihaqi Zein Ahmad, Samudi Samudi
Department of Biology, Faculty of Science and Data Analitics, Institut Teknologi Sepuluh Nopember (ITS), Surabaya, Indonesia.
Divisions of Animal Husbandry, Faculty of Agriculture, Universitas Islam Kadiri, Kediri, Indonesia.
Vet World. 2024 Jun;17(6):1291-1298. doi: 10.14202/vetworld.2024.1291-1298. Epub 2024 Jun 14.
The continuous use of anthelmintic drugs has led to global issues of resistance. One breakthrough to address this problem is the utilization of bio-anthelmintics derived from active compounds in agro-industrial waste. This study investigated the effectiveness of Podang mango ( L.) fruit peel waste extract for anthelmintic purposes, using concentrations up to 5%.
This study included 28 Etawa crossbred goats aged 17 months. Goats were randomly assigned to four groups: A negative control, an aqueous fruit peel extract (AFPE) group at 2.5%, another AFPE group at 5%, and a positive control receiving ivermectin. Goats chosen had egg per gram (EPG) counts surpassing 1000 before exposure to . For 7 days within a 9-week study, AFPE from Podang mangoes was given. On the 7 day, the positive control group was administered ivermectin. AFPE dosage relied on the average abomasum fluid per kilogram of animal weight. The feeding regimen consisted of concentrate and cv. Mott is customized for the nutritional needs of livestock. Data on feed consumption, digestibility, average daily gain, percentage reduction in fecal egg count, body condition score, and clinical parameters were collected throughout the study.
At higher treatment levels (AFPE), there was a greater reduction in both EPG and fecal egg counts. The expected and normal ranges were maintained for consumption and digestibility. While body weight increased, FAMACHA parameters showed a decrease. Compared to the negative control group, substantial disparities (p < 0.05) existed for hemoglobin, red blood cells, and hematocrit in both the positive control and the treatment groups. Blood urea nitrogen and creatinine, indicative of liver and kidney health, were within normal ranges.
At a concentration of up to 5%, Podang mango waste extract (AFPE) can function as a substitute for traditional helminth medicines or bio-anthelmintics in goats, enhancing their production.
驱虫药物的持续使用已引发全球范围内的耐药性问题。解决这一问题的一个突破是利用农业工业废弃物中的活性化合物衍生的生物驱虫剂。本研究调查了高达5%浓度的波当芒果（L.）果皮废弃物提取物用于驱虫目的的有效性。
本研究纳入了28只17月龄的埃塔瓦杂交山羊。山羊被随机分为四组：一个阴性对照组、一个2.5%的果皮水提取物（AFPE）组、另一个5%的AFPE组以及一个接受伊维菌素的阳性对照组。所选山羊在接触前每克粪便虫卵数（EPG）超过1000。在为期9周的研究中，连续7天给予波当芒果的AFPE。在第7天，阳性对照组给予伊维菌素。AFPE剂量依据每千克动物体重的皱胃平均液体量而定。饲养方案包括精饲料和为满足家畜营养需求而定制的cv. Mott。在整个研究过程中收集了饲料消耗、消化率、平均日增重、粪便虫卵计数减少百分比、体况评分和临床参数的数据。
在较高处理水平（AFPE）下，EPG和粪便虫卵计数的降低幅度更大。饲料消耗和消化率维持在预期的正常范围内。虽然体重增加，但FAMACHA参数显示有所下降。与阴性对照组相比，阳性对照组和处理组的血红蛋白、红细胞和血细胞比容存在显著差异（p < 0.05）。表明肝脏和肾脏健康的血尿素氮和肌酐在正常范围内。
浓度高达5%时，波当芒果废弃物提取物（AFPE）可替代山羊传统的驱虫药物或生物驱虫剂，提高其生产性能。
