Department of Nursing, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Tungs' Taichung MetroHarbor Hospital, Taichung, Taiwan.
J Med Internet Res. 2024 Jul 30;26:e57694. doi: 10.2196/57694.
Multidomain interventions have demonstrable benefits for promoting healthy aging, but self-empowerment strategies to sustain long-term gains remain elusive.
This study evaluated the effects of digital somatosensory dance game participation on brain imagery changes as primary outcomes and other physical and mental health measures as secondary outcomes related to healthy aging.
Between August 31, 2020, and June 27, 2021, this randomized controlled trial recruited 60 eligible participants older than 55 years with no recent engagement in digital dance games. A computer-generated randomization sequence was used to allocate participants 1:1, without stratification, to an intervention group (n=30) who underwent digital somatosensory dance game training or a control group (n=30). An anonymized code masked the intervention allocations from the investigators, and individuals who assigned the interventions were not involved in analyzing the study data. The intervention entailed two 30-minute dance game sessions per week for 6 months, and the control group received healthy aging education. Primary outcomes were brain imagery changes. All variables were measured at baseline and the 6-month follow-up, and intervention effects were estimated using t tests with intention-to-treat analyses.
Compared with the control group, intervention participants had significantly different brain imagery in the gray matter volume (GMV) of the left putamen (estimate 0.016, 95% CI 0.008 to 0.024; P<.001), GMV of the left pallidum (estimate 0.02, 95% CI 0.006 to 0.034; P=.004), and fractional amplitude of low frequency fluctuations of the left pallidum (estimate 0.262, 95% CI 0.084 to 0.439; P=.004). Additionally, the intervention group had different imagery in the cerebellum VI GMV (estimate 0.011, 95% CI 0.003 to 0.02; P=.01). The intervention group also had improved total Montreal Cognitive Assessment scores (estimate 1.2, 95% CI 0.27 to -2.13; P<.01), quality of life (estimate 7.08, 95% CI 2.35 to 11.82; P=.004), and time spent sitting on weekdays (estimate -1.96, 95% CI -3.33 to -0.60; P=.005). Furthermore, dance performance was significantly associated with cognitive performance (P=.003), health status (P=.14), resilience (P=.007), and demoralization (P<.001).
Digital somatosensory dance game participation for 6 months was associated with brain imagery changes in multiple regions involving somatosensory, motor, visual, and attention functions, which were consistent with phenotypic improvements associated with healthy aging.
ClinicalTrials.gov NCT05411042; https://clinicaltrials.gov/study/NCT05411042.
多领域干预措施已被证明可促进健康老龄化，但持续获得长期收益的自我赋权策略仍难以捉摸。
本研究评估了数字体感舞蹈游戏参与对大脑成像变化的影响，将其作为主要结果，以及与健康老龄化相关的其他身心健康测量作为次要结果。
在 2020 年 8 月 31 日至 2021 年 6 月 27 日期间，这项随机对照试验招募了 60 名年龄在 55 岁以上且近期未参与数字舞蹈游戏的合格参与者。使用计算机生成的随机序列将参与者 1:1 无分层分配到干预组（n=30）和对照组（n=30）。一个匿名代码屏蔽了干预分配给研究人员，分配干预的人员不参与分析研究数据。干预包括每周进行两次 30 分钟的体感舞蹈游戏，持续 6 个月，对照组接受健康老龄化教育。主要结果是大脑成像变化。所有变量均在基线和 6 个月随访时进行测量，并使用意向治疗分析的 t 检验估计干预效果。
与对照组相比，干预组参与者的左侧壳核（GMV）、左侧苍白球（GMV）和左侧苍白球低频振幅的脑成像存在显著差异（估计值分别为 0.016、0.02 和 0.262，95%CI 分别为 0.008 至 0.024、0.006 至 0.034 和 0.084 至 0.439；P<.001）。此外，干预组在小脑 VI GMV 上存在不同的成像（估计值 0.011，95%CI 0.003 至 0.02；P=.01）。干预组还改善了蒙特利尔认知评估的总分（估计值 1.2，95%CI 0.27 至 -2.13；P<.01）、生活质量（估计值 7.08，95%CI 2.35 至 11.82；P=.004）和工作日久坐时间（估计值 -1.96，95%CI -3.33 至 -0.60；P=.005）。此外，舞蹈表现与认知表现（P=.003）、健康状况（P=.14）、韧性（P=.007）和沮丧（P<.001）显著相关。
6 个月的数字体感舞蹈游戏参与与多个涉及躯体感觉、运动、视觉和注意力功能的区域的大脑成像变化相关，这与与健康老龄化相关的表型改善一致。
ClinicalTrials.gov NCT05411042；https://clinicaltrials.gov/study/NCT05411042。
