Gastrointestinal Cancer Research Center, Non-Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Diabetes Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Sci Rep. 2024 Jul 30;14(1):17577. doi: 10.1038/s41598-024-68569-3.
Studies have shown that the co-occurrence of diabetes mellitus (DM) and thyroid dysfunction (TD) exacerbates diabetes complications and imposes a financial burden on the healthcare system. Therefore, this study aimed to investigate the prevalence of TD-DM comorbidity and its associated risk factors. This cross-sectional study was conducted on enrollment phase data of the TABARI cohort population which consisted of 10,255 adults aged between 35 to 70 years old residing in Sari, Mazandaran, Iran from 2015 to 2017. A total of 9939 out of 10,255 individuals (96.92%) entered the study. The prevalence of TD among T2DM patients was 13.2%. The prevalence of T2DM among patients with TD was 9.2%. Furthermore, the prevalence of TD-DM comorbidity in the overall population was 2.2%. Logistic regression analysis revealed that the odds of TD-DM comorbidity was significantly higher in women (OR 2.85; 95% CI 1.58-5.11), in the age group of 60-70 years (OR 9.62; 95% CI 3.69-25.10), in smokers (OR 2.32; 95% CI 1.19-4.52), in individuals with high waist circumference (WC) (OR 2.22; 95% CI 1.32-3.75), in individuals with low high-density lipoprotein (HDL) (OR 1.60; 95% CI 1.20-2.14), in individuals with high total cholesterol (TC) (OR 1.71; 95% CI 1.21-2.41), in individuals with high triglycerides (TG) (OR 1.79; 95% CI 1.27-2.51), and significantly lower in individuals with higher physical activity (PA) (OR 0.67; 95% CI 0.49-0.93). The present study demonstrated a prevalence of 2.2% in patients with both TD and T2DM. Additionally, female gender, older age, smoking, high WC, low HDL, high TC, high TG, and low PA were predictors of TD-DM comorbidity.
研究表明，糖尿病（DM）和甲状腺功能障碍（TD）同时发生会加重糖尿病并发症，并给医疗保健系统带来经济负担。因此，本研究旨在调查 TD-DM 共病的患病率及其相关危险因素。这项横断面研究是在 2015 年至 2017 年期间，对伊朗马赞达兰省萨里市年龄在 35 至 70 岁之间的 10255 名成年人的 TABARI 队列人群的入组阶段数据进行的。共有 10255 人中的 9939 人（96.92%）进入了研究。T2DM 患者中 TD 的患病率为 13.2%。TD 患者中 T2DM 的患病率为 9.2%。此外，总体人群中 TD-DM 共病的患病率为 2.2%。逻辑回归分析显示，TD-DM 共病的可能性在女性（OR 2.85；95%CI 1.58-5.11）、60-70 岁年龄组（OR 9.62；95%CI 3.69-25.10）、吸烟者（OR 2.32；95%CI 1.19-4.52）、腰围高（OR 2.22；95%CI 1.32-3.75）、高密度脂蛋白（HDL）低（OR 1.60；95%CI 1.20-2.14）、总胆固醇（TC）高（OR 1.71；95%CI 1.21-2.41）、甘油三酯（TG）高（OR 1.79；95%CI 1.27-2.51）个体中显著更高，而在体力活动（PA）较高的个体中显著更低（OR 0.67；95%CI 0.49-0.93）。本研究显示，TD 和 T2DM 患者的患病率为 2.2%。此外，女性、年龄较大、吸烟、高腰围、低 HDL、高 TC、高 TG 和低 PA 是 TD-DM 共病的预测因素。
