用麻风杆菌进行的小鼠脚垫研究——脱氧果糖血清素（DFS）及相关化合物的作用。
Mouse foot-pad studies with M. leprae--effect of desoxy fructo serotonin (DFS) and related compounds.
作者信息
Balakrishnan S, Mester L, Venkataramaniah H N, Bhatia V N
出版信息
Indian J Lepr. 1985 Apr-Jun;57(2):323-8.
Mouse foot-pad experiments were carried out to study the effects of DFS and related compounds on the multiplication of M. leprae. Of the 25 cases clinically suspected Dapsone resistance, 8 were found resistant and 14 sensitive to Dapsone by mouse foot-pad experiments. Six were resistant to DFS and 16 were sensitive. Desoxy fructo 5-hydroxy tryptophane as well as Nutrition Antileprosy (NAL) diet were also found effective in suppressing the growth of M. leprae in mouse foot-pad. Of the two liposoluble derivatives of DFS tested (DFS LS-I and DFS LS-II), DFS LS-II was found more effective in suppressing the growth of M. leprae in foot-pads of mice.
进行小鼠足垫实验以研究二苯砜（DFS）及相关化合物对麻风分枝杆菌增殖的影响。在25例临床疑似对氨苯砜耐药的病例中，通过小鼠足垫实验发现8例对氨苯砜耐药，14例敏感。6例对DFS耐药，16例敏感。脱氧果糖5-羟基色氨酸以及抗麻风营养（NAL）饮食也被发现可有效抑制小鼠足垫中麻风分枝杆菌的生长。在所测试的两种DFS脂溶性衍生物（DFS LS-I和DFS LS-II）中，发现DFS LS-II在抑制小鼠足垫中麻风分枝杆菌生长方面更有效。
Zotero 插件