Bhatia V N, Balakrishnan S, Venkataramaniah H N, Harikrishnan S
Lepr India. 1983 Apr;55(2):247-51.
A retrospective analysis was made of the mouse foot-pad growth of M. leprae from 35 cases of lepromatous leprosy with B.I. ranging from 1.33 to 4.0 (Dharmendra scale). Of these 35 cases, 6 were found to be harbouring dapsone resistant bacilli and 18 cases sensitive bacilli. In 11 of them there was no growth in the control group of animals. The analysis showed that there was no difference in the mean B.I. between those showing no growth and those showing growth in the 1st, 2nd or 3rd harvest. A minimum B.I. around 1.5 is considered adequate for positive foot-pad takes. Another interesting observation made in the study was that the growth rate in the control group foot-pads was consistently higher in mice receiving dapsone resistant bacilli as compared to those inoculated with bacilli, sensitive to the drug.
对35例瘤型麻风患者（细菌指数范围为1.33至4.0，采用达孟德拉分级法）的麻风分枝杆菌在小鼠足垫中的生长情况进行了回顾性分析。在这35例患者中，发现6例携带耐氨苯砜杆菌，18例携带敏感杆菌。其中11例在动物对照组中未出现生长。分析表明，在第1次、第2次或第3次收获时，未生长组和生长组之间的平均细菌指数没有差异。足垫接种成功的细菌指数最低约为1.5。该研究中的另一有趣观察结果是，与接种敏感杆菌的小鼠相比，接种耐氨苯砜杆菌的小鼠对照组足垫中的生长速度始终更高。
