Department of Psychology, University of California, Los Angeles, Los Angeles, California, USA.
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California, USA.
Addict Biol. 2024 Aug;29(8):e13431. doi: 10.1111/adb.13431.
Inflammation appears to be a critical mechanism in the development of alcohol use disorder (AUD) and a consequence of chronic alcohol use. The potential anti-inflammatory properties of cannabis may modulate the proinflammatory effects of alcohol. This study sought to extend previous work investigating the relationship between alcohol consumption, cannabis use and circulating interleukin (IL)-6 levels in a sample with AUD. One hundred and thirty-three individuals with an AUD provided blood samples to assess IL-6 and answered questions regarding alcohol and cannabis use. An ordinary least squares multiple regression analysis was conducted to assess the effect of alcohol and cannabis use on IL-6. A moderation analysis examined cannabis use as a potential moderator of the relationship between alcohol use and circulating IL-6 levels. Alcohol use was predictive of higher log IL-6 levels (standardized β = 0.16, p = 0.03), while cannabis use was not predictive of log IL-6 levels (p = 0.36). Days of cannabis use moderated the relationship between alcohol use and IL-6 levels, such that the relationship between alcohol use and IL-6 levels was only significant in individuals with AUD without recent cannabis use. This study extends previous work to a clinical sample with an AUD and underscores the importance of considering cannabis use in studies on alcohol use and inflammation. This study also indicates the need for in-depth analyses on cannabinoids and inflammation and the interaction between cannabinoids and alcohol use on inflammation.
炎症似乎是酒精使用障碍（AUD）发展的关键机制，也是慢性酒精使用的后果。大麻的潜在抗炎特性可能调节酒精的促炎作用。这项研究旨在扩展之前的工作，即在 AUD 样本中调查酒精消耗、大麻使用和循环白细胞介素（IL）-6 水平之间的关系。133 名 AUD 患者提供了血液样本以评估 IL-6 并回答了关于酒精和大麻使用的问题。进行了普通最小二乘多元回归分析，以评估酒精和大麻使用对 IL-6 的影响。调节分析检查了大麻使用作为酒精使用与循环 IL-6 水平之间关系的潜在调节剂。酒精使用与较高的 log IL-6 水平呈正相关（标准化β=0.16，p=0.03），而大麻使用与 log IL-6 水平无关（p=0.36）。大麻使用天数调节了酒精使用与 IL-6 水平之间的关系，因此，在没有近期大麻使用的 AUD 患者中，酒精使用与 IL-6 水平之间的关系仅具有统计学意义。这项研究将之前的工作扩展到了 AUD 的临床样本，并强调了在酒精使用和炎症研究中考虑大麻使用的重要性。这项研究还表明需要对大麻素和炎症以及大麻素与酒精使用对炎症的相互作用进行深入分析。
