Department of Psychology, Arizona State University.
Exp Clin Psychopharmacol. 2023 Aug;31(4):780-785. doi: 10.1037/pha0000616. Epub 2022 Nov 10.
Emerging adult alcohol and cannabis co-use is on the rise and enacts risk for alcohol misuse/alcohol use disorder (AUD). However, few studies have differentiated whether levels of cannabis use (rather than any cannabis use) moderate between-person risk. Considering low-frequency co-users may use both substances via substitution, low-risk/frequency co-use may not enact the same risk for AUD as higher risk co-use. The present study sought to test this assertion. Public access data on emerging adults from the National Study on Drug Use and Health were used (2002-2019; = 231,681). Participants reported on their past year alcohol use, cannabis use, as well as AUD symptoms. Regression models tested whether levels of cannabis use frequency moderated the association between alcohol use frequency and AUD symptom counts. A significant interaction of cannabis use frequency by alcohol use frequency predicting AUD symptoms was detected. Individuals who co-used alcohol and cannabis reported more AUD symptoms than those who only used alcohol at the same frequency or less. However, co-use was associated with lower AUD symptom counts than alcohol-only use at higher frequency. Findings suggest that all co-users (and alcohol-only users) are not necessarily created equal, and that relations among co-use and risk for AUD symptoms are complex. Rather than a dichotomy of co-users versus alcohol-only users, between-group risk may depend on frequency of both alcohol and cannabis use. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
成年初期同时使用酒精和大麻的现象呈上升趋势，增加了酒精滥用/酒精使用障碍（AUD）的风险。然而，很少有研究区分大麻使用水平（而不是任何大麻使用）是否会在个体之间调节风险。考虑到低频共使用者可能通过替代使用两种物质，低风险/低频率共使用者对 AUD 的风险可能与高风险共使用者不同。本研究旨在检验这一假设。使用了国家药物使用与健康研究（2002-2019 年；n = 231,681）中的成年初期公共访问数据。参与者报告了他们过去一年的饮酒、大麻使用情况以及 AUD 症状。回归模型检验了大麻使用频率是否调节了饮酒频率与 AUD 症状计数之间的关联。大麻使用频率与饮酒频率交互预测 AUD 症状的显著作用。与仅使用相同或更少频率的酒精相比，同时使用酒精和大麻的共使用者报告的 AUD 症状更多。然而，与仅使用酒精的高频率相比，共使用者与较低的 AUD 症状计数相关。研究结果表明，并非所有共使用者（和仅使用酒精的使用者）都是平等的，共使用者与 AUD 症状风险之间的关系是复杂的。与共使用者与仅使用酒精的使用者之间的二分法不同，组间风险可能取决于酒精和大麻使用的频率。（PsycInfo 数据库记录（c）2023 APA，保留所有权利）。
