Department of Pharmacology, Graduate School of Medicine, The University of Tokyo, Bunkyo City, Bunkyo, Japan.
Graduate School of Brain Science, Doshisha University, Kyotanabe, Kyoto, Japan.
Front Neural Circuits. 2024 Jul 19;18:1449459. doi: 10.3389/fncir.2024.1449459. eCollection 2024.
To understand how neurons and neural circuits function during behaviors, it is essential to record neuronal activity in the brain . Among the various technologies developed for recording neuronal activity, molecular tools that induce gene expression in an activity-dependent manner have attracted particular attention for their ability to clarify the causal relationships between neuronal activity and behavior. In this review, we summarize recently developed activity-dependent gene expression tools and their potential contributions to the study of neural circuits.
为了理解神经元和神经回路在行为过程中的功能,有必要记录大脑中的神经元活动。在用于记录神经元活动的各种技术中,那些能够以活动依赖的方式诱导基因表达的分子工具因其能够阐明神经元活动与行为之间的因果关系而受到特别关注。在这篇综述中,我们总结了最近开发的活动依赖性基因表达工具及其对神经回路研究的潜在贡献。