Crabb D W, Li T K
Biochem Genet. 1985 Dec;23(11-12):987-96. doi: 10.1007/BF00499942.
Alcohol dehydrogenase (EC 1.1.1.1) activity was measured in liver extracts from one outbred and three inbred strains of rats. Strain-specific differences in enzyme activity were observed in the adult male rats. The differences appeared as the animals reached puberty. Studies on the enzyme purified from Sprague-Dawley and ACI rats indicate that the enzymes in these strains are identical and that the difference in activity found in liver extracts is due to differences in the amount of enzyme present. Genetic crosses between Sprague-Dawley and ACI rats suggest that the liver content of alcohol dehydrogenase is controlled by an autosomal regulatory locus with the characteristics of a temporal gene.
在一只远交系大鼠和三只近交系大鼠的肝脏提取物中测量了乙醇脱氢酶（EC 1.1.1.1）的活性。在成年雄性大鼠中观察到了酶活性的品系特异性差异。这些差异在动物进入青春期时出现。对从斯普拉格-道利大鼠和ACI大鼠中纯化的酶的研究表明，这些品系中的酶是相同的，并且在肝脏提取物中发现的活性差异是由于存在的酶量不同所致。斯普拉格-道利大鼠和ACI大鼠之间的遗传杂交表明，乙醇脱氢酶的肝脏含量受一个具有时间基因特征的常染色体调节位点控制。
