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气候变化与 COVID-19。

Climate Changes and COVID-19.

机构信息

Faculty of Medicine, Endemic Medicine and Hepatogastroenterology, Cairo University, Giza, Egypt.

出版信息

Adv Exp Med Biol. 2024;1458:217-231. doi: 10.1007/978-3-031-61943-4_14.

Abstract

Climatic change, which influences population growth and land usage, has been theorized to be linked to the emergence and spread of new viruses like the currently unfolding COVID-19 pandemic. In this chapter, we explain how climate change may have altered the beginning, transmission, and maybe even the sickness consequences of the COVID-19 pandemic. Where possible, we also provide mechanistic explanations for how this may have occurred. We have presented evidence that suggests climate change may have had a role in the establishment and transmission of SARS-CoV-2 infection, and most possibly even in some of its clinical effects. Human activities bringing people into closer contact with bats and animals like pangolins that potentially represent the intermediate hosts, and evidence that climate-induced changes in vegetation are the main reservoir source of coronaviruses for human infection, are among the explanations. Although there are still unsubstantiated indications that the first viral pathogen may have escaped from a laboratory, it is possible that this encounter took place in the field or in marketplaces in the instance of COVID-19. We also present the argument that climate change is working to enhance transmission between diseased and uninfected humans, and this is true regardless of the source of the original development of the disease. Changes in temperature and humidity make it easier for viruses to survive, and the impacts of industrial pollution induce people to cough and sneeze, which releases highly infectious aerosols into the air. These three factors combine to make this a more likely scenario than it would otherwise be. We suggest that changes in climate are contributing to create conditions that are favorable for the development of more severe symptoms of illness. It is more difficult to build the argument for this circumstance, and much of it is indirect. However, climate change has caused some communities to adjust their nutritional habits, both in terms of the quantity of food they eat and the quality of the foods they consume. The effects frequently become apparent as a result of alterations that are imposed on the microbiome of the gut, which, in turn, influence the types of immune responses that are produced. The incidence of comorbidities like diabetes and animal vectors like bats that transmit other illnesses that modify vulnerability to SARS-CoV-2 are also two examples of the factors that have been affected by climate change. In order to curb the development of infectious illnesses caused by new viruses, it is necessary to understand the connection between environmental dynamics and the emergence of new coronaviruses. This knowledge should lead to initiatives aimed at reducing global greenhouse gas emissions.

摘要

气候变化影响人口增长和土地利用,有人推测它与新病毒的出现和传播有关,如目前正在发生的 COVID-19 大流行。在本章中,我们解释了气候变化如何改变 COVID-19 大流行的开始、传播,甚至可能改变疾病的后果。在可能的情况下,我们还提供了机制解释,说明这是如何发生的。有证据表明,气候变化可能在 SARS-CoV-2 感染的建立和传播中发挥了作用,而且很可能在其某些临床影响中也发挥了作用。人类活动使人们与蝙蝠和穿山甲等潜在的中间宿主更密切地接触,以及气候引起的植被变化是人类感染冠状病毒的主要储存源的证据,都属于这些解释之一。虽然仍有未经证实的迹象表明,第一种病毒病原体可能是从实验室逃逸出来的,但在 COVID-19 的情况下,这种接触很可能发生在野外或市场上。我们还提出了气候变化正在增强患病者和未感染者之间传播的论点,无论疾病的最初来源如何,这都是事实。温度和湿度的变化使病毒更容易存活,工业污染的影响促使人们咳嗽和打喷嚏,从而将高度传染性的气溶胶释放到空气中。这三个因素结合在一起,使这种情况比其他情况更有可能发生。我们认为,气候变化导致了更有利于疾病发展为更严重症状的条件。要提出这种情况的论据比较困难,而且很多都是间接的。然而,气候变化已经导致一些社区改变了他们的营养习惯,无论是在他们吃的食物数量上,还是在他们吃的食物质量上。这种影响经常由于对肠道微生物组的改变而显现出来,而肠道微生物组的改变又会影响产生的免疫反应类型。糖尿病等合并症的发病率以及传播其他疾病的动物媒介(如蝙蝠)易感染 SARS-CoV-2 的情况,也是受气候变化影响的两个例子。为了遏制新病毒引起的传染病的发展,有必要了解环境动态与新型冠状病毒出现之间的联系。这方面的知识应导致采取减少全球温室气体排放的倡议。

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