School of Biotechnology, RGPV Bhopal, Madhya Pradesh, 462033, India; CSIR-North East Institute of Science and Technology, Jorhat, Assam, 785006, India.
Department of Bioengineering, Integral University, Lucknow 226026, India.
Bioresour Technol. 2024 Sep;408:131211. doi: 10.1016/j.biortech.2024.131211. Epub 2024 Aug 3.
Biosurfactants are surface-active compounds produced by numerous microorganisms. They have gained significant attention due to their wide applications in food, pharmaceuticals, cosmetics, agriculture, and environmental remediation. The production efficiency and yield of microbial biosurfactants have improved significantly through the development and optimization of different process parameters. This review aims to provide an in-depth analysis of recent trends and developments in microbial biosurfactant production strategies, including submerged, solid-state, and co-culture fermentation. Additionally, review discusses biosurfactants' applications, challenges, and future perspectives. It highlights their advantages over chemical surfactants, emphasizing their biodegradability, low toxicity, and diverse chemical structures. However, the critical challenges in commercializing include high production costs and low yield. Strategies like genetic engineering, process optimization, and downstream processing, have been employed to address these challenges. The review provides insights into current commercial producers and highlights future perspectives such as novel bioprocesses, efficient microbial strains, and exploring their applications in emerging industries.
生物表面活性剂是由许多微生物产生的具有表面活性的化合物。由于它们在食品、制药、化妆品、农业和环境修复等领域的广泛应用，它们受到了极大的关注。通过开发和优化不同的工艺参数，微生物生物表面活性剂的生产效率和产量有了显著提高。本综述旨在深入分析微生物生物表面活性剂生产策略的最新趋势和发展，包括浸没法、固态发酵法和共培养发酵法。此外，还讨论了生物表面活性剂的应用、挑战和未来展望。它强调了它们相对于化学表面活性剂的优势，包括生物降解性、低毒性和多样化的化学结构。然而，在商业化方面面临的关键挑战包括高生产成本和低产量。已经采用了基因工程、工艺优化和下游加工等策略来解决这些挑战。该综述提供了对当前商业生产者的见解，并强调了未来的前景，如新型生物工艺、高效微生物菌株以及探索它们在新兴产业中的应用。
