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7T 下骨骼肌质子密度脂肪分数定量的参数优化。

Parameter optimization for proton density fat fraction quantification in skeletal muscle tissue at 7 T.

机构信息

Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.

Division of Medical Physics in Radiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany.

出版信息

MAGMA. 2024 Dec;37(6):969-981. doi: 10.1007/s10334-024-01195-2. Epub 2024 Aug 6.

DOI:10.1007/s10334-024-01195-2
PMID:39105951
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11582128/
Abstract

OBJECTIVE: To establish an image acquisition and post-processing workflow for the determination of the proton density fat fraction (PDFF) in calf muscle tissue at 7 T. MATERIALS AND METHODS: Echo times (TEs) of the applied vendor-provided multi-echo gradient echo sequence were optimized based on simulations of the effective number of signal averages (NSA*). The resulting parameters were validated by measurements in phantom and in healthy calf muscle tissue (n = 12). Additionally, methods to reduce phase errors arising at 7 T were evaluated. Finally, PDFF values measured at 7 T in calf muscle tissue of healthy subjects (n = 9) and patients with fatty replacement of muscle tissue (n = 3) were compared to 3 T results. RESULTS: Simulations, phantom and in vivo measurements showed the importance of using optimized TEs for the fat-water separation at 7 T. Fat-water swaps could be mitigated using a phase demodulation with an additional B map, or by shifting the TEs to longer values. Muscular PDFF values measured at 7 T were comparable to measurements at 3 T in both healthy subjects and patients with increased fatty replacement. CONCLUSION: PDFF determination in calf muscle tissue is feasible at 7 T using a chemical shift-based approach with optimized acquisition and post-processing parameters.

摘要

目的：建立一种用于在 7T 下测量小腿肌肉组织中质子密度脂肪分数（PDFF）的图像采集和后处理工作流程。 材料与方法：根据有效平均信号数（NSA*）模拟，优化了所应用的供应商提供的多回波梯度回波序列的回波时间（TE）。通过在体模和健康小腿肌肉组织（n=12）中的测量来验证得到的参数。此外，还评估了用于减少 7T 时相位误差的方法。最后，将健康受试者（n=9）和肌肉组织脂肪替代患者（n=3）的小腿肌肉组织在 7T 下测量的 PDFF 值与 3T 结果进行比较。 结果：模拟、体模和体内测量均表明在 7T 下使用优化的 TE 进行脂肪-水分离的重要性。使用附加 B 图的相位解调或将 TE 移至更长的值，可以减轻脂肪-水交换。在健康受试者和脂肪替代增加的患者中，在 7T 下测量的肌肉 PDFF 值与在 3T 下的测量值相当。 结论：使用基于化学位移的方法，并优化采集和后处理参数，可在 7T 下对小腿肌肉组织中的 PDFF 进行测定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/11582128/356b62fb680f/10334_2024_1195_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/11582128/09e4fc98b79b/10334_2024_1195_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/11582128/ec6f131dfc44/10334_2024_1195_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/11582128/c033f712e28d/10334_2024_1195_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/11582128/0386f5df3204/10334_2024_1195_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/11582128/43fe9f4f4eef/10334_2024_1195_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/11582128/8237f8b98e0d/10334_2024_1195_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/11582128/63f171de00d8/10334_2024_1195_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/11582128/b9e732bebdac/10334_2024_1195_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/11582128/356b62fb680f/10334_2024_1195_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/11582128/09e4fc98b79b/10334_2024_1195_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/11582128/ec6f131dfc44/10334_2024_1195_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/11582128/c033f712e28d/10334_2024_1195_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/11582128/0386f5df3204/10334_2024_1195_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/11582128/43fe9f4f4eef/10334_2024_1195_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/11582128/8237f8b98e0d/10334_2024_1195_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/11582128/63f171de00d8/10334_2024_1195_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/11582128/b9e732bebdac/10334_2024_1195_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1011/11582128/356b62fb680f/10334_2024_1195_Fig9_HTML.jpg

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Parameter optimization for proton density fat fraction quantification in skeletal muscle tissue at 7 T.

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[2]
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[3]
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[4]
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[6]
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[7]
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[8]
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[9]
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[10]
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引用本文的文献

[1]
Determination of Tissue Potassium and Sodium Concentrations in Dystrophic Skeletal Muscle Tissue Using Combined Potassium (K) and Sodium (Na) MRI at 7 T.

NMR Biomed. 2025-4

本文引用的文献

[1]
Recent technical developments and clinical research applications of sodium (Na) MRI.

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[2]
Muscle architecture is associated with muscle fat replacement in Duchenne and Becker muscular dystrophies.

Muscle Nerve. 2021-11

[3]
Global versus individual muscle segmentation to assess quantitative MRI-based fat fraction changes in neuromuscular diseases.

Eur Radiol. 2021-6

[4]
Improved body quantitative susceptibility mapping by using a variable-layer single-min-cut graph-cut for field-mapping.

Magn Reson Med. 2021-3

[5]
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J Neurol. 2021-3

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NMR Biomed. 2020-2-10

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A Comparison between 6-point Dixon MRI and MR Spectroscopy to Quantify Muscle Fat in the Thigh of Subjects with Sarcopenia.

J Frailty Aging. 2019

[10]
Na MRI depicts early changes in ion homeostasis in skeletal muscle tissue of patients with duchenne muscular dystrophy.

J Magn Reson Imaging. 2019-2-4

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