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脑类器官在糖尿病领域的研究进展。

Research progress of brain organoids in the field of diabetes.

机构信息

Hubei Key Laboratory of Diabetes and Angiopathy, Xianning Medical College, Hubei University of Science and Technology, No.88, Xianning Avenue, Xianan District, Xianning, 437000, Hubei Province, P. R. China.

School of Phamacy, Hubei University of Science and Technology, Xianning, 437000, Hubei Province, P. R. China.

出版信息

Mol Brain. 2024 Aug 6;17(1):53. doi: 10.1186/s13041-024-01123-4.

Abstract

Human embryonic stem cells and human induced pluripotent stem cells may be used to create 3D tissues called brain organoids. They duplicate the physiological and pathological characteristics of human brain tissue more faithfully in terms of both structure and function, and they more precisely resemble the morphology and cellular structure of the human embryonic brain. This makes them valuable models for both drug screening and in vitro studies on the development of the human brain and associated disorders. The technical breakthroughs enabled by brain organoids have a significant impact on the research of different brain regions, brain development and sickness, the connections between the brain and other tissues and organs, and brain evolution. This article discusses the development of brain organoids, their use in diabetes research, and their progress.

摘要

人胚胎干细胞和人诱导多能干细胞可用于创建称为脑类器官的 3D 组织。它们在结构和功能方面更忠实地复制了人类脑组织的生理和病理特征,并且更准确地模拟了人类胚胎大脑的形态和细胞结构。这使得它们成为药物筛选和体外研究人类大脑发育和相关疾病的有价值的模型。脑类器官所带来的技术突破对不同脑区的研究、大脑发育和疾病、大脑与其他组织和器官的联系以及大脑进化都有重大影响。本文讨论了脑类器官的发展、它们在糖尿病研究中的应用以及它们的进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e89f/11304585/ca65c8136760/13041_2024_1123_Fig1_HTML.jpg

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