State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.
State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China.
Biomolecules. 2024 Oct 27;14(11):1364. doi: 10.3390/biom14111364.
Type 2 diabetes mellitus (T2DM), a high-incidence chronic metabolic disorder, has emerged as a global health issue, where most patients need lifelong medication. Gaining insights into molecular mechanisms involved in T2DM development is expected to provide novel strategies for clinical prevention and treatment. Growing evidence validates that non-coding RNAs (ncRNAs) including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) function as crucial regulators in multiple biological processes of T2DM, inspiring various potential targets and drug candidates. In this review, we summarize the current understanding of ncRNA roles in T2DM and discuss the potential use of ncRNAs as targets and active molecules for drug discovery.
2 型糖尿病（T2DM）是一种高发的慢性代谢紊乱疾病，已成为全球性的健康问题，大多数患者需要终身服药。深入了解 T2DM 发展过程中的分子机制有望为临床预防和治疗提供新的策略。越来越多的证据证实，非编码 RNA（ncRNA）包括 microRNAs（miRNAs）、长非编码 RNA（lncRNAs）和环状 RNA（circRNAs）在 T2DM 的多个生物学过程中作为关键调节剂发挥作用，为各种潜在的靶点和药物候选物提供了启示。在这篇综述中，我们总结了 ncRNA 在 T2DM 中的作用的现有认识，并讨论了将 ncRNAs 作为靶点和活性分子用于药物发现的潜力。
