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基因组中组蛋白乙酰转移酶基因家族的鉴定。

Identification of the histone acetyltransferase gene family in the genome.

作者信息

Guo Yang, You Yan, Chen Furong, Liao Yong

机构信息

Department of Pharmacy, Second Clinical Medical College, China Three Gorges University, Yichang, Hubei, China.

出版信息

Front Plant Sci. 2024 Jul 24;15:1389958. doi: 10.3389/fpls.2024.1389958. eCollection 2024.

DOI:10.3389/fpls.2024.1389958
PMID:39114468
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11303224/
Abstract

As the most effective therapeutic drug for malaria, artemisinin can only be extracted from L., which is sensitive to the surrounding growing habitat. Histone acetyltransferases (HATs) contain acetyl groups, which modulate mRNA transcription and thereby regulate plant environmental adaptation. Comprehensive analyses of s have been performed in many plants, but systematic identification of s in medicinal plants is lacking. In the present study, we identified s and characterized these genes into four classes according to their conserved protein structures. According to the phylogenetic analysis results, potential functions of genes from , , and were found. According to our results, has a highly conserved evolutionary history and is rich in highly variable regions; thus, has become a comparatively ideal object of medical plant identification and systematic study. Moreover, motifs commonly present in histone acetyltransferases in the genome may be associated with functional s. s appear to be related to gene-specific functions. AaHATs are regulated by -elements, and these genes may affect phytohormone responsiveness, adaptability to stress, and developmental growth. We performed expression analyses to determine the potential roles of s in response to three environmental stresses. Our results revealed a cluster of that potentially plays a role in the response of plants to dynamic environments.

摘要

作为治疗疟疾最有效的药物,青蒿素只能从对周围生长环境敏感的青蒿中提取。组蛋白乙酰转移酶(HATs)含有乙酰基,可调节mRNA转录,从而调控植物对环境的适应性。许多植物中都对HATs进行了全面分析,但药用植物中HATs的系统鉴定尚属缺乏。在本研究中,我们鉴定了HATs,并根据其保守的蛋白质结构将这些基因分为四类。根据系统发育分析结果,发现了青蒿、黄花蒿和青蒿变种中HAT基因的潜在功能。根据我们的结果,青蒿具有高度保守的进化历史且富含高变区;因此,青蒿已成为药用植物鉴定和系统研究的一个相对理想的对象。此外,青蒿基因组中组蛋白乙酰转移酶中常见的基序可能与功能HATs相关。HATs似乎与基因特异性功能有关。AaHATs受顺式作用元件调控,这些基因可能影响植物激素反应、对胁迫的适应性以及发育生长。我们进行了表达分析以确定HATs在响应三种环境胁迫中的潜在作用。我们的结果揭示了一组可能在植物对动态环境的响应中发挥作用的HATs。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf1/11303224/414eec49542f/fpls-15-1389958-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf1/11303224/fbe1726892db/fpls-15-1389958-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf1/11303224/38424e38354a/fpls-15-1389958-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf1/11303224/990e0a183f00/fpls-15-1389958-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf1/11303224/6dbe8f23fceb/fpls-15-1389958-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf1/11303224/c27cd7ac2387/fpls-15-1389958-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf1/11303224/414eec49542f/fpls-15-1389958-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf1/11303224/fbe1726892db/fpls-15-1389958-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf1/11303224/38424e38354a/fpls-15-1389958-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf1/11303224/990e0a183f00/fpls-15-1389958-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf1/11303224/6dbe8f23fceb/fpls-15-1389958-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf1/11303224/c27cd7ac2387/fpls-15-1389958-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf1/11303224/414eec49542f/fpls-15-1389958-g006.jpg

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本文引用的文献

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Mechanisms of Plant Epigenetic Regulation in Response to Plant Stress: Recent Discoveries and Implications.植物应对胁迫的表观遗传调控机制:最新发现与启示
Plants (Basel). 2024 Jan 7;13(2):163. doi: 10.3390/plants13020163.
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