Çakır Bozkurt Gökçen, Yoleri Levent, Temiz Peyker
Department of Plastic, Reconstructive and Aesthetic Surgery Manisa, Faculty of Medicine, Manisa Celal Bayar University, Manisa, Turkey.
Department of Pathology, Faculty of Medicine, Manisa Celal Bayar University, Manisa, Turkey.
Aesthetic Plast Surg. 2024 Dec;48(23):5155-5161. doi: 10.1007/s00266-024-04267-9. Epub 2024 Aug 8.
Fat grafts are widely used in plastic, aesthetic and reconstructive surgery. Their unpredictable resorption is their main disadvantage. A review of the literature shows that there is a lack of research on the effect of mobile and immobile regions on fat graft survival in fat graft applications.
Our aim was to investigate the relationship of fat graft survival with mobile and immobile region in a new experimental model.
Twenty-four male Wistar albino rats were randomly divided into two groups (n=12). Fat grafts were harvested from the right inguinal region of the rat. In Group 1, the fat graft was placed in the subcutaneous pouch formed in the scalp region of the rat. In Group 2, fat grafts were placed in the pouch formed in the posterior cervical region of the rat. At the end of 6 weeks, the weights and histopathology of the fat grafts were evaluated. Histopathological examinations were performed in a blinded fashion.
The weights of the fat grafts were found to be higher in Group 1. At the same time, histopathological examinations showed that vascular density was higher in Group 1. There was no statistically significant difference in other histopathological examinations.
The mobile and immobile areas may have different effects on the survival of transplanted fat grafts. Sliding movement between muscle and skin in the mobile zone puts stress on the fat graft. In our study, the mobile site was shown to have a negative effect on the vascularity of the fat graft. It was observed that the vascular density was higher in the fat graft placed in the immobilised area. Further studies on the increase in vascularity can be carried out using the new experimental model we have created.
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脂肪移植广泛应用于整形、美容和重建手术。其不可预测的吸收是其主要缺点。文献综述表明，在脂肪移植应用中，关于活动区域和非活动区域对脂肪移植存活影响的研究较少。
我们的目的是在一个新的实验模型中研究脂肪移植存活与活动区域和非活动区域的关系。
将24只雄性Wistar白化大鼠随机分为两组（n = 12）。从大鼠右侧腹股沟区域采集脂肪移植物。在第1组中，将脂肪移植物置于大鼠头皮区域形成的皮下袋中。在第2组中，将脂肪移植物置于大鼠颈后区域形成的袋中。6周结束时，评估脂肪移植物的重量和组织病理学。组织病理学检查采用盲法进行。
发现第1组脂肪移植物的重量更高。同时，组织病理学检查显示第1组的血管密度更高。在其他组织病理学检查中没有统计学显著差异。
活动区域和非活动区域可能对移植脂肪移植物的存活有不同影响。活动区域中肌肉和皮肤之间的滑动运动会给脂肪移植物带来压力。在我们的研究中，活动部位对脂肪移植物的血管形成有负面影响。观察到置于固定区域的脂肪移植物中血管密度更高。可以使用我们创建的新实验模型对血管形成增加进行进一步研究。
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