McLatchie G R, Allister C, MacEwen C, Hamilton G, McGregor H, Colquhuon I, Pickvance N J
Br J Sports Med. 1985 Dec;19(4):203-6. doi: 10.1136/bjsm.19.4.203.
In a study of 144 patients, with Grade 1 and 2 inversion injuries to the ankle sustained in sport, treatment with a non-steroidal anti-inflammatory was considerably superior to placebo with respect to joint tenderness, level of training and injury severity. No difference in efficacy could be determined between ibuprofen 2400 mg given in two or four equally divided daily doses. Ten patients withdrew from the study because of side effects, five from ibuprofen twice daily, three from ibuprofen four times daily and two from the placebo group. This study confirms the efficacy, flexibility and tolerability of high dose ibuprofen.
在一项针对144名在运动中脚踝遭受1级和2级内翻损伤患者的研究中，就关节压痛、训练水平和损伤严重程度而言，使用非甾体抗炎药治疗明显优于安慰剂。每日分两次或四次服用2400毫克布洛芬，疗效并无差异。10名患者因副作用退出研究，其中5名来自每日服用两次布洛芬的组，3名来自每日服用四次布洛芬的组，2名来自安慰剂组。本研究证实了高剂量布洛芬的疗效、灵活性和耐受性。
