Dupont M, Béliveau P, Thériault G
Am J Sports Med. 1987 Jan-Feb;15(1):41-5. doi: 10.1177/036354658701500106.
The value of nonsteroidal antiinflammatory drugs in the treatment of various sports-related injuries has been investigated by several groups. Despite these efforts, the experimental results are difficult to interpret, and very few investigations have focused on a single injury type in the acute phase. A double-blind study compared ibuprofen at a dose of 2,400 mg per day and a placebo in the 1st week of treatment of 61 acute ankle sprains with varying degrees of severity. Medical evaluation by the same physician was performed on the 1st, 4th, 8th, and 28th day following the injury. Subjective evaluation of pain, number of painful ligaments at palpation, passive mobilization induced pain, edema, and functional incapacity served as the clinical parameters. Although there were trends indicating a superiority of effectiveness in the treatment group, the differences between groups were not statistically significant.
几组研究人员对非甾体抗炎药在治疗各种运动相关损伤中的价值进行了调查。尽管做出了这些努力，但实验结果仍难以解释，而且很少有研究聚焦于急性期的单一损伤类型。一项双盲研究比较了每天服用2400毫克布洛芬和安慰剂对61例不同严重程度急性踝关节扭伤治疗第一周的效果。在受伤后的第1天、第4天、第8天和第28天，由同一位医生进行医学评估。疼痛的主观评估、触诊时疼痛韧带的数量、被动活动引起的疼痛、水肿和功能丧失作为临床参数。尽管有趋势表明治疗组在有效性方面具有优势，但两组之间的差异无统计学意义。
