• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

禽流感病毒 A(H5Nx)和大流行前候选疫苗：最新进展。

Avian Influenza Virus A(H5Nx) and Prepandemic Candidate Vaccines: State of the Art.

机构信息

North-Western Tuscany Blood Bank, Pisa University Hospital, 56100 Pisa, Italy.

Laboratory of Virology, National Institute for Infectious Diseases "Lazzaro Spallanzani"-IRCCS, 00149 Rome, Italy.

出版信息

Int J Mol Sci. 2024 Aug 5;25(15):8550. doi: 10.3390/ijms25158550.

DOI:10.3390/ijms25158550
PMID:39126117
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11312817/
Abstract

Avian influenza virus has been long considered the main threat for a future pandemic. Among the possible avian influenza virus subtypes, A(HN) clade 2.3.4.4b is becoming enzootic in mammals, representing an alarming step towards a pandemic. In particular, genotype B3.13 has recently caused an outbreak in US dairy cattle. Since pandemic preparedness is largely based on the availability of prepandemic candidate vaccine viruses, in this review we will summarize the current status of the enzootics, and challenges for H vaccine manufacturing and delivery.

摘要

禽流感病毒一直被认为是未来大流行的主要威胁。在可能的禽流感病毒亚型中，A(HN) 分支 2.3.4.4b 在哺乳动物中成为地方流行病毒，这是向大流行迈出的令人震惊的一步。特别是，基因型 B3.13 最近在美国奶牛中引发了一次疫情。由于大流行的准备工作在很大程度上依赖于备灾候选疫苗病毒的供应，因此在这篇综述中，我们将总结地方流行的现状，以及 H 疫苗制造和输送的挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1137/11312817/14fff2428bbf/ijms-25-08550-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1137/11312817/14fff2428bbf/ijms-25-08550-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1137/11312817/14fff2428bbf/ijms-25-08550-g001.jpg

相似文献

1
Avian Influenza Virus A(H5Nx) and Prepandemic Candidate Vaccines: State of the Art.禽流感病毒 A(H5Nx)和大流行前候选疫苗：最新进展。
Int J Mol Sci. 2024 Aug 5;25(15):8550. doi: 10.3390/ijms25158550.
2
Antigenic and genetic characteristics of influenza A(H5N1) and influenza A(H9N2) viruses for development of candidate vaccines viruses for pandemic preparedness - February 2011.用于大流行防范的甲型流感病毒A(H5N1)和A(H9N2)候选疫苗病毒研发的抗原及基因特征——2011年2月
Wkly Epidemiol Rec. 2011 Mar 11;86(11):93-100.
3
Recombinant parainfluenza virus 5 expressing clade 2.3.4.4b H5 hemagglutinin protein confers broad protection against H5Ny influenza viruses.表达 2.3.4.4b 分支 H5 血凝素蛋白的重组副流感病毒 5 可提供针对 H5Ny 流感病毒的广泛保护。
J Virol. 2024 Mar 19;98(3):e0112923. doi: 10.1128/jvi.01129-23. Epub 2024 Feb 2.
4
Pandemic preparedness through vaccine development for avian influenza viruses.通过开发针对禽流感病毒的疫苗做好大流行的准备。
Hum Vaccin Immunother. 2024 Dec 31;20(1):2347019. doi: 10.1080/21645515.2024.2347019. Epub 2024 May 28.
5
Antigenic and genetic characteristics of zoonotic influenza viruses and development of candidate vaccine viruses for pandemic preparedness.人畜共患流感病毒的抗原和基因特征以及用于大流行防范的候选疫苗病毒的研发。
Wkly Epidemiol Rec. 2011 Oct 21;86(43):469-80.
6
H5N1 outbreaks and enzootic influenza.H5N1禽流感疫情与地方性流感
Emerg Infect Dis. 2006 Jan;12(1):3-8. doi: 10.3201/eid1201.051024.
7
Development of a new candidate H5N1 avian influenza virus for pre-pandemic vaccine production.开发一种新的 H5N1 禽流感候选病毒用于大流行前疫苗生产。
Influenza Other Respir Viruses. 2009 Nov;3(6):287-95. doi: 10.1111/j.1750-2659.2009.00104.x.
8
Cross-Protection by Inactivated H5 Prepandemic Vaccine Seed Strains against Diverse Goose/Guangdong Lineage H5N1 Highly Pathogenic Avian Influenza Viruses.灭活 H5 疫苗种株对不同鸭/广东谱系 H5N1 高致病性禽流感病毒的交叉保护作用。
J Virol. 2020 Nov 23;94(24). doi: 10.1128/JVI.00720-20.
9
Antigenic and genetic characteristics of influenza A(H5N1) viruses and candidate vaccine viruses developed for potential use in human vaccines.甲型流感病毒（H5N1）的抗原性和基因特性以及为人类疫苗潜在应用而研发的候选疫苗病毒。
Wkly Epidemiol Rec. 2009 Oct 9;84(41):432-6.
10
Antigenic and genetic characteristics of influenza A(H5N1) and influenza A(H9N2) viruses and candidate vaccine viruses developed for potential use in human vaccines - February 2010.甲型流感病毒（H5N1）和甲型流感病毒（H9N2）的抗原及基因特征，以及为用于人类疫苗而研发的候选疫苗病毒——2010年2月
Wkly Epidemiol Rec. 2010 Mar 12;85(11):100-7.

引用本文的文献

1
H5N1 Avian Influenza: A Narrative Review of Scientific Advances and Global Policy Challenges.H5N1禽流感：科学进展与全球政策挑战的叙述性综述
Viruses. 2025 Jun 29;17(7):927. doi: 10.3390/v17070927.
2
Computationally designed haemagglutinin with nanocage plug-and-display elicits pan-H5 influenza vaccine responses.通过纳米笼插入展示进行计算设计的血凝素引发泛H5流感疫苗反应。
Emerg Microbes Infect. 2025 Dec;14(1):2511132. doi: 10.1080/22221751.2025.2511132. Epub 2025 Jul 11.
3
Design, Synthesis and Evaluation of a Candidate Fusion Epitopic Construct Vaccine Based on M2e, HA1, HA2, NA and NP Fragments of the Highly Pathogenic Avian H5N1 Influenza Virus.

本文引用的文献

1
Strain-dependent variations in replication of European clade 2.3.4.4b influenza A(H5N1) viruses in bovine cells and thermal inactivation in semi-skimmed or whole milk.欧洲分支 2.3.4.4b 型流感 A(H5N1)病毒在牛细胞中的复制具有株系依赖性差异及在半脱脂或全脂牛奶中的热失活动力学。
Euro Surveill. 2024 Jul;29(30). doi: 10.2807/1560-7917.ES.2024.29.30.2400436.
2
Spillover of highly pathogenic avian influenza H5N1 virus to dairy cattle.高致病性禽流感 H5N1 病毒向奶牛的溢出。
Nature. 2024 Oct;634(8034):669-676. doi: 10.1038/s41586-024-07849-4. Epub 2024 Jul 25.
3
A Randomized, Placebo-Controlled Trial to Evaluate the Safety and Efficacy of VIR-2482 in Healthy Adults for Prevention of Influenza A Illness (PENINSULA).
基于高致病性H5N1禽流感病毒M2e、HA1、HA2、NA和NP片段的候选融合表位构建疫苗的设计、合成与评价
Arch Razi Inst. 2024 Aug 1;79(4):849-856. doi: 10.32592/ARI.2024.79.4.849. eCollection 2024 Aug.
4
Highly pathogenic avian influenza H5N1: history, current situation, and outlook.高致病性禽流感H5N1：历史、现状与展望
J Virol. 2025 Apr 15;99(4):e0220924. doi: 10.1128/jvi.02209-24. Epub 2025 Mar 27.
5
Dose-Dependent Effect of DNA Vaccine pVAX-H5 Encoding a Modified Hemagglutinin of Influenza A (H5N8) and Its Cross-Reactivity Against A (H5N1) Influenza Viruses of Clade 2.3.4.4b.编码甲型流感病毒（H5N8）修饰血凝素的DNA疫苗pVAX-H5的剂量依赖性效应及其对2.3.4.4b分支甲型（H5N1）流感病毒的交叉反应性
Viruses. 2025 Feb 27;17(3):330. doi: 10.3390/v17030330.
6
Could H5N1 bird flu virus be the cause of the next human pandemic?H5N1禽流感病毒会是下一次人类大流行的病因吗？
Front Microbiol. 2024 Oct 8;15:1477738. doi: 10.3389/fmicb.2024.1477738. eCollection 2024.
一项评估 VIR-2482 在健康成年人中预防甲型流感疾病（PENINSULA）的安全性和有效性的随机、安慰剂对照试验。
Clin Infect Dis. 2024 Oct 15;79(4):1054-1061. doi: 10.1093/cid/ciae368.
4
Genomic characterization of highly pathogenic avian influenza A H5N1 virus newly emerged in dairy cattle.奶牛中新出现的高致病性禽流感 A(H5N1)病毒的基因组特征
Emerg Microbes Infect. 2024 Dec;13(1):2380421. doi: 10.1080/22221751.2024.2380421. Epub 2024 Jul 24.
5
Detection and characterization of H5N1 HPAIV in environmental samples from a dairy farm.从一个奶牛场的环境样本中检测和分析 H5N1 高致病性禽流感病毒。
Virus Genes. 2024 Oct;60(5):517-527. doi: 10.1007/s11262-024-02085-4. Epub 2024 Jul 15.
6
Pathogenicity and transmissibility of bovine H5N1 influenza virus.牛源 H5N1 流感病毒的致病性和传染性。
Nature. 2024 Sep;633(8029):426-432. doi: 10.1038/s41586-024-07766-6. Epub 2024 Jul 8.
7
Persistence of Influenza H5N1 and H1N1 Viruses in Unpasteurized Milk on Milking Unit Surfaces.挤奶设备表面未经巴氏消毒的牛奶中流感 H5N1 和 H1N1 病毒的持续存在。
Emerg Infect Dis. 2024 Aug;30(8):1721-1723. doi: 10.3201/eid3008.240775. Epub 2024 Jun 24.
8
Rapid mortality in captive bush dogs () caused by influenza A of avian origin (H5N1) at a wildlife collection in the United Kingdom.在英国的一个野生动物收藏馆中，由于禽流感 H5N1 引发的甲型流感，圈养的鬃狼（）迅速死亡。
Emerg Microbes Infect. 2024 Dec;13(1):2361792. doi: 10.1080/22221751.2024.2361792. Epub 2024 Jun 5.
9
Cow's Milk Containing Avian Influenza A(H5N1) Virus - Heat Inactivation and Infectivity in Mice.含甲型禽流感病毒（H5N1）的牛奶——热灭活及对小鼠的感染性
N Engl J Med. 2024 Jul 4;391(1):87-90. doi: 10.1056/NEJMc2405495. Epub 2024 May 24.
10
Antibodies to Influenza A(H5N1) Virus in Hunting Dogs Retrieving Wild Fowl, Washington, USA.美国华盛顿州猎鸭犬体内的 H5N1 型流感病毒抗体
Emerg Infect Dis. 2024 Jun;30(6):1271-1274. doi: 10.3201/eid3006.231459.